Trans Fatty Acids, HDL-cholesterol, and Cardiovascular Disease. Effects of Dietary Changes on Vascular Reactivity

N.M. de Roos, E.G. Schouten, M.B. Katan

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

A high consumption of trans fatty acids increases the risk of cardiovascular disease (CVD). We investigeted whether this increase in risk was due to the decrease in serum HDL-cholesterol by trans fatty acids, because low concentrations of serum HDL-cholesterol also increase risk of CVD. Flow-mediated vasodilation (FMD) was used as an endpoint in dietary interventions that were designed to change the concentration of serum HDL-cholesterol within 4 weeks in healthy volunteers. Replacement of 10% of energy from saturated by trans fatty acids decreased serum HDL-cholesterol by 21 % and impaired FMD. However, a replacement of monounsaturated fats by carbohydrates did not impair FMD, although it decreased serum HDL-cholesterol by 13%. Acute postprandial impairments of FMD by either trans fats or saturated fats were not found, suggesting that long-term effects are responsible for the detrimental effect of trans fats on health. However, the role of serum HDL-cholesterol appears to be less than we expected.
Original languageEnglish
Pages (from-to)355-357
JournalEuropean Journal of Medical Research
Volume8
Publication statusPublished - 2003

Keywords

  • flow-mediated vasodilation
  • healthy-men
  • replacement
  • women

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