Trafficking and endocytosis of BRI1 and SERK receptors

J.C.M. Aker

Research output: Thesisinternal PhD, WU

Abstract

To be able to react on environmental changes, plants use receptors on their cell membranes. Receptors in the plasma membrane catch signals via their extracellular domain and transduce these to other proteins. The receptors studied in this thesis are part of the brassinosteroid signaling pathway in Arabidopsis. The main receptor BRI1 binds brassinosteroids (BRs), upon which dimerization with the co-receptors SERK3 and SERK1 takes place. Receptors are removed from the plasma membrane to end up in small vesicles, the endosomes. From endosomes, either signaling or degradation of the receptors takes place.
The interaction between the SERK1 receptor and the CDC48A protein might be based on the mediation of degradation of mis-folded SERK1 proteins from the ER (endoplasmic reticulum) in the proteasome, in a quality control-like fashion. The co-receptors SERK1 and SERK3 are required for BR signaling, that takes place from the endosomes and not or less from BR signaling from the plasma membrane.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • de Vries, Sacco, Promotor
  • Borst, Jan Willem, Co-promotor
Award date8 Oct 2008
Place of Publication[S.l.]
Print ISBNs9789085852063
Publication statusPublished - 2008

Keywords

  • arabidopsis
  • endocytosis
  • signal peptide
  • signal transduction
  • biochemical receptors

Fingerprint

Dive into the research topics of 'Trafficking and endocytosis of BRI1 and SERK receptors'. Together they form a unique fingerprint.

Cite this