Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts

R. Ashauer; A. Agatz; C. Albert; V. Ducrot; N.G. Galic; J. Hendriks; T. Jager; A. Kretschmann; I. O'Connor; M.N. Rubach; M. Nyman; W. Schmitt; J. Stadnicka; P.J. van den Brink

doi:10.1002/etc.639

Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts

R. Ashauer, A. Agatz, C. Albert, V. Ducrot, N.G. Galic, J. Hendriks, T. Jager, A. Kretschmann, I. O'Connor, M.N. Rubach, M. Nyman, W. Schmitt, J. Stadnicka, P.J. van den Brink

Research output: Contribution to journal › Article › Academic › peer-review

63 Citations (Scopus)

Abstract

We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined

Original language	English
Pages (from-to)	2519-2524
Journal	Environmental Toxicology and Chemistry
Volume	30
Issue number	11
DOIs	https://doi.org/10.1002/etc.639
Publication status	Published - 2011

Keywords

time-varying concentrations
biology-based approach
gammarus-pulex
daphnia-magna
population-dynamics
organic-chemicals
mixture toxicity
pulsed exposure
binary-mixtures
hyalella-azteca

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10.1002/etc.639

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CREAM: Mechanistic Effect Models for the Ecological Risk Assessment of Chemicals
1/09/09 → 31/07/14
Project: EU research project

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Ashauer, R., Agatz, A., Albert, C., Ducrot, V., Galic, N. G., Hendriks, J., Jager, T., Kretschmann, A., O'Connor, I., Rubach, M. N., Nyman, M., Schmitt, W., Stadnicka, J., & van den Brink, P. J. (2011). Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts. Environmental Toxicology and Chemistry, 30(11), 2519-2524. https://doi.org/10.1002/etc.639

Ashauer, R. ; Agatz, A. ; Albert, C. ; Ducrot, V. ; Galic, N.G. ; Hendriks, J. ; Jager, T. ; Kretschmann, A. ; O'Connor, I. ; Rubach, M.N. ; Nyman, M. ; Schmitt, W. ; Stadnicka, J. ; van den Brink, P.J. / Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts. In: Environmental Toxicology and Chemistry. 2011 ; Vol. 30, No. 11. pp. 2519-2524.

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title = "Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts",

abstract = "We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined",

keywords = "time-varying concentrations, biology-based approach, gammarus-pulex, daphnia-magna, population-dynamics, organic-chemicals, mixture toxicity, pulsed exposure, binary-mixtures, hyalella-azteca",

author = "R. Ashauer and A. Agatz and C. Albert and V. Ducrot and N.G. Galic and J. Hendriks and T. Jager and A. Kretschmann and I. O'Connor and M.N. Rubach and M. Nyman and W. Schmitt and J. Stadnicka and {van den Brink}, P.J.",

year = "2011",

doi = "10.1002/etc.639",

language = "English",

volume = "30",

pages = "2519--2524",

journal = "Environmental Toxicology and Chemistry",

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Ashauer, R, Agatz, A, Albert, C, Ducrot, V, Galic, NG, Hendriks, J, Jager, T, Kretschmann, A, O'Connor, I, Rubach, MN, Nyman, M, Schmitt, W, Stadnicka, J & van den Brink, PJ 2011, 'Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts', Environmental Toxicology and Chemistry, vol. 30, no. 11, pp. 2519-2524. https://doi.org/10.1002/etc.639

Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts. / Ashauer, R.; Agatz, A.; Albert, C.; Ducrot, V.; Galic, N.G.; Hendriks, J.; Jager, T.; Kretschmann, A.; O'Connor, I.; Rubach, M.N.; Nyman, M.; Schmitt, W.; Stadnicka, J.; van den Brink, P.J.

In: Environmental Toxicology and Chemistry, Vol. 30, No. 11, 2011, p. 2519-2524.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts

AU - Ashauer, R.

AU - Agatz, A.

AU - Albert, C.

AU - Ducrot, V.

AU - Galic, N.G.

AU - Hendriks, J.

AU - Jager, T.

AU - Kretschmann, A.

AU - O'Connor, I.

AU - Rubach, M.N.

AU - Nyman, M.

AU - Schmitt, W.

AU - Stadnicka, J.

AU - van den Brink, P.J.

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KW - time-varying concentrations

KW - biology-based approach

KW - gammarus-pulex

KW - daphnia-magna

KW - population-dynamics

KW - organic-chemicals

KW - mixture toxicity

KW - pulsed exposure

KW - binary-mixtures

KW - hyalella-azteca

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JO - Environmental Toxicology and Chemistry

JF - Environmental Toxicology and Chemistry

SN - 0730-7268

IS - 11

ER -

Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts

Abstract

Keywords

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CREAM: Mechanistic Effect Models for the Ecological Risk Assessment of Chemicals

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