Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts

R. Ashauer; A. Agatz; C. Albert; V. Ducrot; N.G. Galic; J. Hendriks; T. Jager; A. Kretschmann; I. O'Connor; M.N. Rubach; M. Nyman; W. Schmitt; J. Stadnicka; P.J. van den Brink

doi:10.1002/etc.639

Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts

R. Ashauer, A. Agatz, C. Albert, V. Ducrot, N.G. Galic, J. Hendriks, T. Jager, A. Kretschmann, I. O'Connor, M.N. Rubach, M. Nyman, W. Schmitt, J. Stadnicka, P.J. van den Brink

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined

Original language	English
Pages (from-to)	2519-2524
Journal	Environmental Toxicology and Chemistry
Volume	30
Issue number	11
DOIs	https://doi.org/10.1002/etc.639
Publication status	Published - 2011

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Keywords

time-varying concentrations
biology-based approach
gammarus-pulex
daphnia-magna
population-dynamics
organic-chemicals
mixture toxicity
pulsed exposure
binary-mixtures
hyalella-azteca

Cite this

Ashauer, R., Agatz, A., Albert, C., Ducrot, V., Galic, N. G., Hendriks, J., ... van den Brink, P. J. (2011). Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts. Environmental Toxicology and Chemistry, 30(11), 2519-2524. https://doi.org/10.1002/etc.639

Ashauer, R. ; Agatz, A. ; Albert, C. ; Ducrot, V. ; Galic, N.G. ; Hendriks, J. ; Jager, T. ; Kretschmann, A. ; O'Connor, I. ; Rubach, M.N. ; Nyman, M. ; Schmitt, W. ; Stadnicka, J. ; van den Brink, P.J. / Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts. In: Environmental Toxicology and Chemistry. 2011 ; Vol. 30, No. 11. pp. 2519-2524.

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abstract = "We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined",

keywords = "time-varying concentrations, biology-based approach, gammarus-pulex, daphnia-magna, population-dynamics, organic-chemicals, mixture toxicity, pulsed exposure, binary-mixtures, hyalella-azteca",

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Ashauer, R, Agatz, A, Albert, C, Ducrot, V, Galic, NG, Hendriks, J, Jager, T, Kretschmann, A, O'Connor, I, Rubach, MN, Nyman, M, Schmitt, W, Stadnicka, J & van den Brink, PJ 2011, 'Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts', Environmental Toxicology and Chemistry, vol. 30, no. 11, pp. 2519-2524. https://doi.org/10.1002/etc.639

Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts. / Ashauer, R.; Agatz, A.; Albert, C.; Ducrot, V.; Galic, N.G.; Hendriks, J.; Jager, T.; Kretschmann, A.; O'Connor, I.; Rubach, M.N.; Nyman, M.; Schmitt, W.; Stadnicka, J.; van den Brink, P.J.

In: Environmental Toxicology and Chemistry, Vol. 30, No. 11, 2011, p. 2519-2524.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Ashauer, R.

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KW - gammarus-pulex

KW - daphnia-magna

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KW - organic-chemicals

KW - mixture toxicity

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KW - binary-mixtures

KW - hyalella-azteca

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Access to Document

10.1002/etc.639