Towards PAT bioprocess monitoring and control: near infrared and software sensor

Z.I.T.A. Soons, M. Streefland, A.J.B. van Boxtel

Research output: Contribution to conferenceConference paperAcademicpeer-review

Abstract

Abstract Two advanced techniques have been compared to enhance bioprocess monitoring and control by online reconstruction of biomass and specific growth rate for feedback control: a software sensor based on standard measurements of the oxygen uptake rate and inline near infrared spectroscopy. An automatic search method for wavelength selection was proposed to enhance the prection ability of the near infrared method. Both techniques perform well, however when it comes to feedback control, the software sensor is preferred, because it is more robust against variations in the operating conditions and noise. The results are shown on real cultivations of Bordetella pertussis.
Original languageEnglish
Publication statusPublished - 2009
EventCHEMPOR 2008 -
Duration: 4 Sep 20086 Sep 2008

Conference

ConferenceCHEMPOR 2008
Period4/09/086/09/08

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Near infrared spectroscopy
Feedback control
Biomass
Infrared radiation
Oxygen
Monitoring
Sensors

Cite this

Soons, Z. I. T. A., Streefland, M., & van Boxtel, A. J. B. (2009). Towards PAT bioprocess monitoring and control: near infrared and software sensor. Paper presented at CHEMPOR 2008, .
Soons, Z.I.T.A. ; Streefland, M. ; van Boxtel, A.J.B. / Towards PAT bioprocess monitoring and control: near infrared and software sensor. Paper presented at CHEMPOR 2008, .
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abstract = "Abstract Two advanced techniques have been compared to enhance bioprocess monitoring and control by online reconstruction of biomass and specific growth rate for feedback control: a software sensor based on standard measurements of the oxygen uptake rate and inline near infrared spectroscopy. An automatic search method for wavelength selection was proposed to enhance the prection ability of the near infrared method. Both techniques perform well, however when it comes to feedback control, the software sensor is preferred, because it is more robust against variations in the operating conditions and noise. The results are shown on real cultivations of Bordetella pertussis.",
author = "Z.I.T.A. Soons and M. Streefland and {van Boxtel}, A.J.B.",
year = "2009",
language = "English",
note = "CHEMPOR 2008 ; Conference date: 04-09-2008 Through 06-09-2008",

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Soons, ZITA, Streefland, M & van Boxtel, AJB 2009, 'Towards PAT bioprocess monitoring and control: near infrared and software sensor' Paper presented at CHEMPOR 2008, 4/09/08 - 6/09/08, .

Towards PAT bioprocess monitoring and control: near infrared and software sensor. / Soons, Z.I.T.A.; Streefland, M.; van Boxtel, A.J.B.

2009. Paper presented at CHEMPOR 2008, .

Research output: Contribution to conferenceConference paperAcademicpeer-review

TY - CONF

T1 - Towards PAT bioprocess monitoring and control: near infrared and software sensor

AU - Soons, Z.I.T.A.

AU - Streefland, M.

AU - van Boxtel, A.J.B.

PY - 2009

Y1 - 2009

N2 - Abstract Two advanced techniques have been compared to enhance bioprocess monitoring and control by online reconstruction of biomass and specific growth rate for feedback control: a software sensor based on standard measurements of the oxygen uptake rate and inline near infrared spectroscopy. An automatic search method for wavelength selection was proposed to enhance the prection ability of the near infrared method. Both techniques perform well, however when it comes to feedback control, the software sensor is preferred, because it is more robust against variations in the operating conditions and noise. The results are shown on real cultivations of Bordetella pertussis.

AB - Abstract Two advanced techniques have been compared to enhance bioprocess monitoring and control by online reconstruction of biomass and specific growth rate for feedback control: a software sensor based on standard measurements of the oxygen uptake rate and inline near infrared spectroscopy. An automatic search method for wavelength selection was proposed to enhance the prection ability of the near infrared method. Both techniques perform well, however when it comes to feedback control, the software sensor is preferred, because it is more robust against variations in the operating conditions and noise. The results are shown on real cultivations of Bordetella pertussis.

M3 - Conference paper

ER -

Soons ZITA, Streefland M, van Boxtel AJB. Towards PAT bioprocess monitoring and control: near infrared and software sensor. 2009. Paper presented at CHEMPOR 2008, .