Toward a new european threshold to discriminate illegally administered from naturally occurring thiouracil in livestock

Jella Wauters, Julie Vanden Bussche, Bruno Le Bizec, J.A.L. Kiebooms, Gaud Dervilly-Pinel, Stéphanie Prevost, Barbara Wozniak, S.S. Sterk, Dag Grønningen, D.G. Kennedy, Sandra Russell, Philippe Delahaut, Lynn Vanhaecke*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Thiouracil is a thyrostat inhibiting the thyroid function, resulting in fraudulent weight gain if applied in the fattening of livestock. The latter abuse is strictly forbidden and monitored in the European Union. Recently, endogenous sources of thiouracil were identified after frequently monitoring low-level thiouracil positive urine samples and a "recommend concentration" (RC) of 10 ∼g/L was suggested by the EURL to facilitate decision-making. However, the systematic occurrence of urine samples exceeding the RC led to demands for international surveys defining an epidemiologic threshold. Therefore, six European member states (France, Poland, The Netherlands, United Kingdom, Norway, and Belgium) have shared their official thiouracil data (2010-2012) collected from bovines, porcines, and small livestock with 95 and 99% percentiles of 8.1 and 18.2 ∼g/L for bovines (n = 3894); 7.4 and 13.5 ∼g/L for porcines (n = 654); and 7.4 ∼g/L (95% only) for small livestock (n = 85), respectively. Bovine percentiles decreased with the animal age (nonadults had significantly higher levels for bovines), and higher levels were observed in male bovines compared to female bovines.

Original languageEnglish
Pages (from-to)1339-1346
JournalJournal of Agricultural and Food Chemistry
Volume63
Issue number5
DOIs
Publication statusPublished - 2015

Keywords

  • endogenous
  • European
  • LC-MS/MS
  • thiouracil
  • threshold
  • urine

Fingerprint Dive into the research topics of 'Toward a new european threshold to discriminate illegally administered from naturally occurring thiouracil in livestock'. Together they form a unique fingerprint.

  • Cite this

    Wauters, J., Vanden Bussche, J., Bizec, B. L., Kiebooms, J. A. L., Dervilly-Pinel, G., Prevost, S., Wozniak, B., Sterk, S. S., Grønningen, D., Kennedy, D. G., Russell, S., Delahaut, P., & Vanhaecke, L. (2015). Toward a new european threshold to discriminate illegally administered from naturally occurring thiouracil in livestock. Journal of Agricultural and Food Chemistry, 63(5), 1339-1346. https://doi.org/10.1021/jf504475f