Total synthesis and bioactivity of some naturally occurring pterulones

B.W.T. Gruijters, A. van Veldhuizen, C.A.G.M. Weijers, J.B.P.A. Wijnberg

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)


The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (6) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of Rhodotorula glutinis and Saccharomyces cerevisiae.
Original languageEnglish
Pages (from-to)558-561
JournalJournal of Natural Products
Issue number4
Publication statusPublished - 2002


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