Time dependent responses of glycocolytic intermediates in a detailed glycolytic model of Lactococcus lactis during glucose run-out experiments

M.H. Hoefnagel, A. van der Burgt, D.E. Martens, J. Hugenholtz, J.L. Snoep

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Abstract

Glucose addition and subsequent run-out experiments were compared to simulations with a detailed glycolytic model of Lactococcus lactis. The model was constructed largely on bases of enzyme kinetic data taken from literature and not adjusted for the specific simulations shown here. Upon glucose depletion a rapid increase in PEP, inorganic phosphate and a gradual decrease in fructose 1,6-bisphosphate (FBP) were measured and predicted by simulation. The dynamic changes in these and other intermediate concentrations as measured in the experiments were well predicted by the kinetic model
Original languageEnglish
Pages (from-to)157-161
JournalMolecular Biology Reports
Volume29
Issue number1-2
DOIs
Publication statusPublished - 2002

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