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Abstract
Trypanosomes are pathogenic unicellular eukaryotic flagellates, with a broad host range, they can be found in many vertebrate species, causing diseases in cold-blooded as well as livestock and humans. Owing to their pathogenicity and unicellular eukaryotic nature trypanosomes have attracted the attention of researchers trying to unravel fundamental questions about cell biology and pathogenicity of these parasites.
The current thesis aimed to: 1) establish an in vivo trypanosome infection model in zebrafish using a fish-specific trypanosome; 2) investigate the behaviour of trypanosomes in vivo, in a natural host environment; 3) characterize the general (innate) immune response to the infection in young zebrafish, and 4) study the biological properties of transmembrane Tnfα, which was previously associated with protection against trypanosome infections.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 5 Jun 2019 |
Place of Publication | Wageningen |
Publisher | |
Print ISBNs | 9789463439480 |
DOIs | |
Publication status | Published - 5 Jun 2019 |
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Dive into the research topics of 'Through the looking glass: trypanosome infections in zebrafish: seeing is believing'. Together they form a unique fingerprint.Projects
- 1 Finished
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Biological activities of membrane and soluble TNFalpha and establishment of the trypanosome model in zebrafish
Dóró, É. (PhD candidate), Forlenza, M. (Promotor) & Wiegertjes, G. (Promotor)
1/05/12 → 5/06/19
Project: PhD