Through the looking glass: trypanosome infections in zebrafish

seeing is believing

Éva Dóró

Research output: Thesisinternal PhD, WU

Abstract

Trypanosomes are pathogenic unicellular eukaryotic flagellates, with a broad host range, they can be found in many vertebrate species, causing diseases in cold-blooded as well as livestock and humans. Owing to their pathogenicity and unicellular eukaryotic nature trypanosomes have attracted the attention of researchers trying to unravel fundamental questions about cell biology and pathogenicity of these parasites.

The current thesis aimed to: 1) establish an in vivo trypanosome infection model in zebrafish using a fish-specific trypanosome; 2) investigate the behaviour of trypanosomes in vivo, in a natural host environment; 3) characterize the general (innate) immune response to the infection in young zebrafish, and 4) study the biological properties of transmembrane Tnfα, which was previously associated with protection against trypanosome infections.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Forlenza, Maria, Promotor
  • Wiegertjes, Geert, Promotor
Award date5 Jun 2019
Place of PublicationWageningen
Publisher
Print ISBNs9789463439480
DOIs
Publication statusPublished - 2019

Fingerprint

Trypanosomiasis
Zebrafish
Glass
Infection
Virulence
Host Specificity
Livestock
Innate Immunity
Cell Biology
Vertebrates
Fishes
Parasites
Research Personnel

Cite this

Dóró, Éva. / Through the looking glass: trypanosome infections in zebrafish : seeing is believing. Wageningen : Wageningen University, 2019. 206 p.
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title = "Through the looking glass: trypanosome infections in zebrafish: seeing is believing",
abstract = "Trypanosomes are pathogenic unicellular eukaryotic flagellates, with a broad host range, they can be found in many vertebrate species, causing diseases in cold-blooded as well as livestock and humans. Owing to their pathogenicity and unicellular eukaryotic nature trypanosomes have attracted the attention of researchers trying to unravel fundamental questions about cell biology and pathogenicity of these parasites. The current thesis aimed to: 1) establish an in vivo trypanosome infection model in zebrafish using a fish-specific trypanosome; 2) investigate the behaviour of trypanosomes in vivo, in a natural host environment; 3) characterize the general (innate) immune response to the infection in young zebrafish, and 4) study the biological properties of transmembrane Tnfα, which was previously associated with protection against trypanosome infections.",
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Dóró, E 2019, 'Through the looking glass: trypanosome infections in zebrafish: seeing is believing', Doctor of Philosophy, Wageningen University, Wageningen. https://doi.org/10.18174/475570

Through the looking glass: trypanosome infections in zebrafish : seeing is believing. / Dóró, Éva.

Wageningen : Wageningen University, 2019. 206 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Through the looking glass: trypanosome infections in zebrafish

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