Thermosensitive and photocleavable polyaspartamide derivatives for drug delivery

Xiao Du, Yibo Jiang, Renxi Zhuo, Xulin Jiang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


The development of novel thermo- and photo-dual-responsive biodegradable polymeric micelles based on amphiphilic polyaspartamide derivatives (NB-g-PHPA-g-mPEG) for anticancer drug delivery is reported. The obtained polymers containing hydrophobic photocleavable o-nitrobenzyl groups exhibit thermo- and photosensitivity. The micelles and paclitaxel-loaded micelles based on the thermo- and photo-dual-sensitive polymers were prepared by a quick heating method without using toxic organic solvent. The paclitaxel release from the drug-loaded micelles can be triggered under photoirradiation. Enhancement of the anticancer activity against HeLa cells was observed for paclitaxel-loaded NB-g-PHPA-g-mPEG micelles after light irradiation, while the empty NB-g-PHPA-g-mPEG micelles with or without irradiation did not show any toxicity. Therefore, the thermo- and photo-dual-responsive NB-g-PHPA-g-mPEG micelles have a promising future applied as a light controlled drug delivery system for anticancer drugs.

Original languageEnglish
Pages (from-to)2855-2863
Number of pages9
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number18
Publication statusPublished - 25 Jun 2016


  • drug delivery systems
  • nanoparticles
  • photosensitivity
  • poly(amino acid)
  • stimuli-sensitive polymers

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