Thermodynamics of fibrillar protein aggregation

A. Kroes-Nijboer; P. Venema; E. van der Linden

Thermodynamics of fibrillar protein aggregation

A. Kroes-Nijboer, P. Venema, E. van der Linden

Research output: Contribution to conference › Poster › Professional

Abstract

Aggregation of globular proteins into fibrils seems to be a generic form of aggregation. However, the exact mechanism of fibril formation is still unclear. One of the questions is whether the aggregation is an enthalpy- or an entropy-driven process. We measured the critical aggregation concentration versus temperature for the fibril formation of ß-lg at pH 2 and used this data to calculate the thermodynamic parameters for the aggregation process. Keywords: fibrillar aggregation, CAC, binding energy, entropy

Original language	English
Publication status	Published - 2007
Event	Nationale MicroNano Conferentie - Duration: 15 Nov 2007 → 16 Nov 2007

Conference/symposium

Conference/symposium	Nationale MicroNano Conferentie
Period	15/11/07 → 16/11/07

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http://www.minacned.nl/micronanoconferentie2007/media/postersabstracts/2B_Nijboer.pdf

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title = "Thermodynamics of fibrillar protein aggregation",

abstract = "Aggregation of globular proteins into fibrils seems to be a generic form of aggregation. However, the exact mechanism of fibril formation is still unclear. One of the questions is whether the aggregation is an enthalpy- or an entropy-driven process. We measured the critical aggregation concentration versus temperature for the fibril formation of {\ss}-lg at pH 2 and used this data to calculate the thermodynamic parameters for the aggregation process. Keywords: fibrillar aggregation, CAC, binding energy, entropy",

author = "A. Kroes-Nijboer and P. Venema and {van der Linden}, E.",

note = "F865; Nationale MicroNano Conferentie ; Conference date: 15-11-2007 Through 16-11-2007",

year = "2007",

language = "English",

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TY - CONF

T1 - Thermodynamics of fibrillar protein aggregation

AU - Kroes-Nijboer, A.

AU - Venema, P.

AU - van der Linden, E.

N1 - F865

PY - 2007

Y1 - 2007

N2 - Aggregation of globular proteins into fibrils seems to be a generic form of aggregation. However, the exact mechanism of fibril formation is still unclear. One of the questions is whether the aggregation is an enthalpy- or an entropy-driven process. We measured the critical aggregation concentration versus temperature for the fibril formation of ß-lg at pH 2 and used this data to calculate the thermodynamic parameters for the aggregation process. Keywords: fibrillar aggregation, CAC, binding energy, entropy

AB - Aggregation of globular proteins into fibrils seems to be a generic form of aggregation. However, the exact mechanism of fibril formation is still unclear. One of the questions is whether the aggregation is an enthalpy- or an entropy-driven process. We measured the critical aggregation concentration versus temperature for the fibril formation of ß-lg at pH 2 and used this data to calculate the thermodynamic parameters for the aggregation process. Keywords: fibrillar aggregation, CAC, binding energy, entropy

M3 - Poster

T2 - Nationale MicroNano Conferentie

Y2 - 15 November 2007 through 16 November 2007

ER -

Thermodynamics of fibrillar protein aggregation

Abstract

Conference/symposium

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