The zebrafish as a model to study intestinal inflammation

Sylvia Brugman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

78 Citations (Scopus)

Abstract

Starting out as a model for developmental biology, during the last decade, zebrafish have also gained the attention of the immunologists and oncologists. Due to its small size, high fecundity and full annotation of its genome, the zebrafish is an attractive model system. The fact that fish are transparent early in life combined with the growing list of immune cell reporter fish, enables in vivo tracking of immune responses in a complete organism. Since zebrafish develop ex utero from a fertilized egg, immune development can be monitored from the start of life. Given that several gut functions and immune genes are conserved between zebrafish and mammals, the zebrafish is an interesting model organism to investigate fundamental processes underlying intestinal inflammation and injury. This review will first provide some background on zebrafish intestinal development, bacterial colonization and immunity, showing the similarities and differences compared to mammals. This will be followed by an overview of the existing models for intestinal disease, and concluded by future perspectives in light of the newest technologies and insights.

Original languageEnglish
Pages (from-to)82-92
JournalDevelopmental and Comparative Immunology
Volume64
DOIs
Publication statusPublished - 2016

Keywords

  • Enterocolitis
  • Immunity
  • Inflammation
  • Intestines
  • Zebrafish

Fingerprint Dive into the research topics of 'The zebrafish as a model to study intestinal inflammation'. Together they form a unique fingerprint.

  • Cite this