The VAO/PCMH flavoprotein family

Tom A. Ewing, Marco W. Fraaije, Andrea Mattevi, Willem J.H. van Berkel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)


The VAO/PCMH flavoprotein family consists of structurally homologous flavin-dependent enzymes that catalyze a wide range of chemical reactions. Family members share an architecture consisting of a conserved FAD-binding domain and a more variable substrate-binding domain, which enables varying interactions with a range of substrates while maintaining the same cofactor-binding fold. Here, we provide an overview of the current state of our knowledge on the members of the VAO/PCMH family. Based on a phylogenetic analysis, we divide the family into 11 subgroups. We discuss the properties of these subgroups, focusing on recent developments in terms of the discovery of new family members and mechanistic advances. We also highlight open questions that will provide challenges for future research.
Original languageEnglish
Pages (from-to)104-117
JournalArchives of Biochemistry and Biophysics
Early online date2017
Publication statusPublished - 15 Oct 2017


  • Enzyme mechanism
  • Flavoprotein
  • Oxidoreductase
  • Phylogeny
  • Protein family

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