The use of mushroom-forming fungi for the production of N-glycosylated therapeutic proteins

E. Berends, K. Scholtmeijer, H.A.B. Wösten, H.J. Bosch, L.G. Lugones

    Research output: Contribution to journalArticleAcademicpeer-review

    19 Citations (Scopus)

    Abstract

    The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. This requires cost-effective production platforms that display correct and homogeneous N-glycosylation. Based on recent results, we propose to use mushroom-forming basidiomycetes for the production of N-glycosylated therapeutic proteins
    Original languageEnglish
    Pages (from-to)439-443
    JournalTrends in Microbiology
    Volume17
    Issue number10
    DOIs
    Publication statusPublished - 2009

    Keywords

    • basidiomycete schizophyllum-commune
    • filamentous fungi
    • pichia-pastoris
    • oligosaccharides
    • laccase
    • glycans
    • scale
    • roles
    • yeast

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