The transmission characteristics of A/Chicken/Pennsylvania/83 influenza virus, an experimental approach

J.A. van der Goot, G. Koch, M.C.M. de Jong, R.M. van Boven

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

High-pathogenicity avian influenza (HPAI) viruses emerged from low-pathogenicity avian influenza (LPAI) viruses in Pennsylvania (1983-84), Mexico (1994-95), and Italy (1999-2000). Here we focus on the question of why the HPAI virus supersedes the LPAI virus, once it has appeared during the epidemic. To study this, we used an experimental model in chickens that enabled us to estimate the reproduction ratio (R-0). Using this model, we determined the R-0 of the A/Chicken/Pennsylvania/21525/83 (LPAI) and of the A/Chicken/ Pennsylvania/ 1370/83 (HPAI). Comparing the R-0 of both viruses, we concluded that the R-0 of the HPAI virus is significantly higher than the R-0 of the LPAI.
Original languageEnglish
Pages (from-to)939-941
JournalAvian Diseases
Volume47
Issue numbers3
DOIs
Publication statusPublished - 2003

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