The Sw-5 gene cluster: Tomato breeding and research toward orthotospovirus disease control

Athos S. de Oliveira*, Leonardo S. Boiteux, Richard Kormelink, Renato O. Resende

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

33 Citations (Scopus)


The Sw-5 gene cluster encodes protein receptors that are potentially able to recognize microbial products and activate signaling pathways that lead to plant cell immunity. Although there are several Sw-5 homologs in the tomato genome, only one of them, named Sw-5b, has been extensively studied due to its functionality against a wide range of (thrips-transmitted) orthotospoviruses. The Sw-5b gene is a dominant resistance gene originally from a wild Peruvian tomato that has been used in tomato breeding programs aiming to develop cultivars with resistance to these viruses. Here, we provide an overview starting from the first reports of Sw-5 resistance, positional cloning and the sequencing of the Sw-5 gene cluster from resistant tomatoes and the validation of Sw-5b as the functional protein that triggers resistance against orthotospoviruses. Moreover, molecular details of this plant–virus interaction are also described, especially concerning the roles of Sw-5b domains in the sensing of orthotospoviruses and in the signaling cascade leading to resistance and hypersensitive response.

Original languageEnglish
Article number1055
JournalFrontiers in Plant Science
Publication statusPublished - 19 Jul 2018


  • NB-LRR
  • NLR
  • Orthotospovirus
  • Resistance
  • Sw-5
  • Sw-5b
  • Tomato


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