The Secretory Function of Adipocytes in the Physiology of White Adipose Tissue

P. Wang, E. Mariman, J. Renes, J. Keijer

    Research output: Contribution to journalArticleAcademicpeer-review

    228 Citations (Scopus)


    White adipose tissue, previously regarded as a passive lipid storage site, is now viewed as a dynamic tissue. It has the capacity to actively communicate by sending and receiving different types of signals. An overview of these signals, the external modulators that affect adipose tissue and the secreted signaling molecules, the adipokines, is presented. The secretory function is highlighted in relation to energy metabolism, inflammation and the extracellular matrix and placed in the context of adipose tissue biology. We observe that the endocrine function of adipocytes receives much attention, while its paracrine and autocrine functions are underestimated. Also, we provide examples that species specificity should not be neglected. We conclude that adipose tissue primarily is an energy storage organ, well supported by its secretory function
    Original languageEnglish
    Pages (from-to)3-13
    JournalJournal of Cellular Physiology
    Issue number1
    Publication statusPublished - 2008


    • colony-enhancing factor
    • type-2 diabetes-mellitus
    • migration inhibitory factor
    • mature 3t3-l1 adipocytes
    • necrosis-factor-alpha
    • insulin-resistance
    • gene-expression
    • mitochondrial biogenesis
    • metabolic syndrome
    • in-vivo


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