The role of red processed meat in colorectal cancer development a perspective

M. Oostindjer, J. Alexander, G.V. Amdam, G. Andersen, N.S. Bryan, D. Chen, D.E. Corpet, S. de Smet, L.O. Dragsted, A. Haug, A.H. Karlsson, G.A. Kleter, E.J. Kok, B. Kulseng, A.L. Milkowski, R.J. Martin, A.M. Pajari, J.E. Paulsen, J. Pickova, K. RudiM. Sodring, D.L. Weed, B. Egelandsdal

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111 Citations (Scopus)

Abstract

This paper is based on a workshop held in Oslo, Norway in November 2013, in which experts discussed how to reach consensus on the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake of red and processed meat to reduce cancer risk, in particular colorectal cancer (CRC). Epidemiological and mechanistic data on associations between red and processed meat intake and CRC are inconsistent and underlying mechanisms are unclear. There is a need for further studies on differences between white and red meat, between processed and whole red meat and between different types of processed meats, as potential health risks may not be the same for all products. Better biomarkers of meat intake and of cancer occurrence and updated food composition databases are required for future studies. Modifying meat composition via animal feeding and breeding, improving meat processing by alternative methods such as adding phytochemicals and improving our diets in general are strategies that need to be followed up.
Original languageEnglish
Pages (from-to)583-596
JournalMeat Science
Volume97
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • mucin-depleted foci
  • aberrant crypt foci
  • endothelium-dependent vasodilation
  • familial adenomatous polyposis
  • colonic epithelial-cells
  • n-3 fatty-acids
  • dna-damage
  • intestinal tumorigenesis
  • microtubule stability
  • potential mechanisms

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