The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

D.I. Viegas Calcada; D. Vianello; E. Giampieri; C. Sala; G. Castellani; A. de Graaf; B. Kremer; B. van Ommen; E.J.M. Feskens; A. Santoro; C. Franceschi; J. Bouwman

doi:10.1016/j.mad.2014.01.004

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

D.I. Viegas Calcada, D. Vianello, E. Giampieri, C. Sala, G. Castellani, A. de Graaf, B. Kremer, B. van Ommen, E.J.M. Feskens, A. Santoro, C. Franceschi, J. Bouwman

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems

Original language	English
Pages (from-to)	138-147
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	136-137
DOIs	https://doi.org/10.1016/j.mad.2014.01.004
Publication status	Published - 2014

Keywords

nf-kappa-b
microarray experiment miame
minimum information
innate immunity
quantitative-analysis
interaction networks
insulin-resistance
cell biology
data sets
t-cells

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10.1016/j.mad.2014.01.004Licence: CC BY-NC-SA

NU-AGE: New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe
1/05/11 → 30/04/16
Project: EU research project

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Viegas Calcada, D. I., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E. J. M., Santoro, A., Franceschi, C., & Bouwman, J. (2014). The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach. Mechanisms of Ageing and Development, 136-137, 138-147. https://doi.org/10.1016/j.mad.2014.01.004

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title = "The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach",

abstract = "Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems",

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year = "2014",

doi = "10.1016/j.mad.2014.01.004",

language = "English",

volume = "136-137",

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journal = "Mechanisms of Ageing and Development",

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Viegas Calcada, DI, Vianello, D, Giampieri, E, Sala, C, Castellani, G, de Graaf, A, Kremer, B, van Ommen, B, Feskens, EJM, Santoro, A, Franceschi, C & Bouwman, J 2014, 'The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach', Mechanisms of Ageing and Development, vol. 136-137, pp. 138-147. https://doi.org/10.1016/j.mad.2014.01.004

TY - JOUR

T1 - The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

AU - Viegas Calcada, D.I.

AU - Vianello, D.

AU - Giampieri, E.

AU - Sala, C.

AU - Castellani, G.

AU - de Graaf, A.

AU - Kremer, B.

AU - van Ommen, B.

AU - Feskens, E.J.M.

AU - Santoro, A.

AU - Franceschi, C.

AU - Bouwman, J.

PY - 2014

Y1 - 2014

N2 - Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems

AB - Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems

KW - nf-kappa-b

KW - microarray experiment miame

KW - minimum information

KW - innate immunity

KW - quantitative-analysis

KW - interaction networks

KW - insulin-resistance

KW - cell biology

KW - data sets

KW - t-cells

U2 - 10.1016/j.mad.2014.01.004

DO - 10.1016/j.mad.2014.01.004

M3 - Article

SN - 0047-6374

VL - 136-137

SP - 138

EP - 147

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Abstract

Keywords

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NU-AGE: New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe

Cite this