Abstract
In Sudan, the incidence of hepatocellular carcinoma (HCC) is high and increasing. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are important risk factors of HCC. This study aims to assess the role of HBV and HCV infections in the incidence of HCC in 2 regions of Sudan. A case-control study was conducted in 1996-98 among 150 HCC patients and 205 controls from 2 regions in Sudan. Their demographic characteristics as well as food habits and chronic conditions have been investigated. In this study, 115 cases and 199 controls were tested for hepatitis B surface antigen (HBsAg) and for HCV antibodies. Strong positive associations were found between HBV or HCV, and HCC with odds ratios (ORs) 9.8 (95␌I 5.1-18.9) and 8.3 (95␌I 2.3-29.9), respectively. After adjustment for age, by logistic regression, the ORs for HBV and HCV were 16.1 (95␌I 7.4-34.9) and 4.5 (95␌I 1.1-18.6), respectively. Further adjustment for region, education level and job type did not appreciably affect the results. Given a prevalence of HBV and HCV of 7.0nd 1.5mong controls, about 57␘f all HCC cases can be attributed to these viral infections. Hepatitis infections seem to be important risk factors for HCC in Sudan.
Original language | English |
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Pages (from-to) | 487-491 |
Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
Volume | 95 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Hepatitis B virus
- Hepatitis C virus
- Hepatocellular carcinoma
- Prevalence
- Risk factors
- Sudan