The role of hepatitis B and hepatitis C viral infections in the incidence of hepatocellular carcinoma in Sudan

R.E. Omer, P. van 't Veer, A.M.Y. Kadaru, E. Kampman, I.M.E. Khidir, S.S. Fedail, F.J. Kok

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

In Sudan, the incidence of hepatocellular carcinoma (HCC) is high and increasing. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are important risk factors of HCC. This study aims to assess the role of HBV and HCV infections in the incidence of HCC in 2 regions of Sudan. A case-control study was conducted in 1996-98 among 150 HCC patients and 205 controls from 2 regions in Sudan. Their demographic characteristics as well as food habits and chronic conditions have been investigated. In this study, 115 cases and 199 controls were tested for hepatitis B surface antigen (HBsAg) and for HCV antibodies. Strong positive associations were found between HBV or HCV, and HCC with odds ratios (ORs) 9.8 (95␌I 5.1-18.9) and 8.3 (95␌I 2.3-29.9), respectively. After adjustment for age, by logistic regression, the ORs for HBV and HCV were 16.1 (95␌I 7.4-34.9) and 4.5 (95␌I 1.1-18.6), respectively. Further adjustment for region, education level and job type did not appreciably affect the results. Given a prevalence of HBV and HCV of 7.0nd 1.5mong controls, about 57␘f all HCC cases can be attributed to these viral infections. Hepatitis infections seem to be important risk factors for HCC in Sudan.
Original languageEnglish
Pages (from-to)487-491
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume95
Issue number5
DOIs
Publication statusPublished - 2001

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