The role of cytokines in ultraviolet-B induced immunosuppression

A. Boonstra, H.F.J. Savelkoul

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


Summary : Cytokines play an important role in the mechanisms resulting in ultraviolet B-induced immunosuppression. They play a crucial role in the induction of local as well as systemic immunomodulatory events. Ultraviolet B irradiation directly induces the release of cytokines in the epidermis, resulting in complex and diverse interactions on epidermal cells, which results in migration out of the skin and infiltration into the skin of different cell types. Partly because of the interaction of locally produced cytokines with antigen-presenting cells, systemic effects, such as antigen-specific tolerance, can be observed. This review describes the different mechanisms whereby ultraviolet B exposure affects immune functions with special emphasis on the role of T-cell subsets and cytokines. Keywords : cytokine, ultraviolet radiation, UVB, immunosuppression, T-cell subsets, photoimmunology
Original languageEnglish
Pages (from-to)117-123
JournalEuropean Cytokine Network
Issue number2
Publication statusPublished - 1997
Externally publishedYes


  • Cytokine
  • Immunosuppression
  • Photoimmunology
  • T-cell subsets
  • Ultraviolet radiation
  • UVB


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