The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose-response meta-analysis

V. Hall Moran, A.L. Stammers, M. Wharton Medina, S. Patel, F. Dykes, O.W. Souverein, C. Dullemeijer, C. Perez-Rodrigo, L. Serra-Majem, M. Nissensohn, N.M.M. Lowe

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Abstract

Recommendations for zinc intake during childhood vary widely across Europe. The EURRECA project attempts to consolidate the basis for the definition of micronutrient requirements, taking into account relationships among intake, status and health outcomes, in order to harmonise these recommendations. Data on zinc intake and biomarkers of zinc status reported in randomised controlled trials (RCTs) can provide estimates of dose-response relationships which may be used for underpinning zinc reference values. This systematic review included all RCTs of apparently healthy children aged 1–17 years published by February 2010 which provided data on zinc intake and biomarkers of zinc status. An intake-status regression coefficient () was calculated for each individual study and calculated the overall pooled and SE () using random effects meta-analysis on a double log scale. The pooled dose-response relationship between zinc intake and zinc status indicated that a doubling of the zinc intake increased the serum/plasma zinc status by 9%. This evidence can be utilised, together with currently used balance studies and repletion/depletion studies, when setting zinc recommendations as a basis for nutrition policies.
Original languageEnglish
Pages (from-to)841-858
JournalNutrients
Volume4
Issue number8
DOIs
Publication statusPublished - 2012

Keywords

  • iron supplementation
  • preschool-children
  • body-composition
  • micronutrient requirements
  • mexican preschoolers
  • adolescent girls
  • lactating women
  • school-children
  • vitamin-a
  • growth

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