The public health risks of enterobacterial isolates producing extended-spectrum Beta-lactamases (ESBL) or AmpC Beta-lactamases in food and food-producing animals: An EU perspective of epidemiology, analytical methods, risk factors and control options

E. Liebana, A. Carattoli, T.M. Coque, H. Hasman, A.P. Magiorakos, D.J. Mevius, L. Peixe, G. Schuepbach-Regula, K. Torneke, J. Torren-Edo, C. Torres, J. Threlfall

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156 Citations (Scopus)

Abstract

blaESBL and blaAmpC in Enterobacteriaceae are spread by plasmid-mediated integrons, insertion sequences and transposons, some of which are homologous in bacteria from food-animals, foods and humans. These genes have been frequently identified in Escherichia coli and Salmonella from food-animals; the most common genes being blaCTX-M-1, blaCTX-M-14, and blaCMY-2. Identification of risk factors for their occurrence in food-animals is complex. As well as generic antimicrobial use, cephalosporin usage is an important risk factor for selection and spread of these genes. Extensive international trade of animals is a further risk factor. There are no data on the effectiveness of individual control options in reducing public health risks. A highly effective option would be to stop or restrict cephalosporin usage in food-animals. Decreasing total antimicrobial use is also of high priority. Implementation of measures to limit strain dissemination (increasing farm biosecurity, controls in animal trade, and other general post-harvest controls) are also important.
Original languageEnglish
Pages (from-to)1030-1037
JournalClinical infectious diseases
Volume56
Issue number7
DOIs
Publication statusPublished - 2013

Keywords

  • escherichia-coli
  • salmonella-enterica
  • ctx-m
  • antimicrobial resistance
  • plasmids
  • poultry
  • strains
  • farms
  • spain
  • identification

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