The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors

W.A. van Gemert, C.I. Lanting, R.A. Goldbohm, P.A. van den Brandt, H.G. Grooters, E. Kampman, L.A.L.M. Kiemeney, F.E. van Leeuwen, E.M. Monninkhof, E. de Vries, P.H. Peeters, S.G. Elias

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18 Citations (Scopus)

Abstract

We aimed to estimate the proportion of Dutch postmenopausal breast cancer cases in 2010 that is attributable to lifestyle-related risk factors. We calculated population attributable fractions (PAFs) of potentially modifiable risk factors for postmenopausal breast cancer in Dutch women aged >50 in 2010. First, age-specific PAFs were calculated for each risk factor, based on their relative risks for postmenopausal breast cancer (from meta-analyses) and age-specific prevalence in the population (from national surveys) around the year 2000, assuming a latency period of 10 years. To obtain the overall PAF, age-specific PAFs were summed in a weighted manner, using the age-specific breast cancer incidence rates (2010) as weights. 95 % confidence intervals for PAF estimates were derived by Monte Carlo simulations. Of Dutch women >40 years, in 2000, 51 % were overweight/obese, 55 % physically inactive (

Original languageEnglish
Pages (from-to)155-162
JournalBreast Cancer Research and Treatment
Volume152
Issue number1
DOIs
Publication statusPublished - 5 Jun 2015

Keywords

  • Lifestyle-related risk factors
  • Population attributable fraction
  • Postmenopausal breast cancer

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