The presence of co-infections in pigs with clinical signs of PMWS in the Nethrlands: a case-control study

G.J. Wellenberg, N. Stockhofe, W.J.A. Boersma, M.F. Jong, A.R.W. Elbers

    Research output: Contribution to journalArticleAcademicpeer-review

    56 Citations (Scopus)

    Abstract

    In this study, 60 pigs with clinical signs of post-weaning multisystemic wasting syndrome (PMWS) from 20 different pig herds and 180 control pigs (without clinical signs of PMWS) were examined to get more insights into the frequencies of porcine circovirus 2 infections and the presence of co-infections in pigs with and without clinical signs of PMWS in the Netherlands. Porcine circovirus type 2 was detected in 100% of the pigs with clinical signs of PMWS by virus isolation and/or PCR and in 50% of the pigs from PMWS-free herds. There was an association between the levels of infectious PCV2 and/or PCV2 DNA load and the severity of clinical signs as described for PMWS. A high variation in PCV2 antibody titres was found in the clinically affected pigs, and 27% of these pigs did not mount PCV2 antibody titres higher than 1:200. A concurrent infection of PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) was found in at least 83% of the pigs with clinical signs of PMWS and in 35% of the pigs from PMWS-free herds. Co-infections of European- and American-type PRRSV were detected only in PMWS herds and in one control herd with a history of PMWS clinical signs
    LanguageEnglish
    Pages177-184
    JournalResearch in Veterinary Science
    Volume77
    Issue number2
    DOIs
    Publication statusPublished - 2004

    Fingerprint

    Wasting Syndrome
    wasting syndrome
    Weaning
    case-control studies
    Coinfection
    mixed infection
    Case-Control Studies
    weaning
    Swine
    swine
    herds
    Circovirus
    Porcine respiratory and reproductive syndrome virus
    Porcine circovirus-2
    Porcine reproductive and respiratory syndrome virus
    Circoviridae Infections
    antibodies
    Antibodies
    Netherlands

    Keywords

    • multisystemic wasting syndrome
    • respiratory syndrome virus
    • porcine circovirus type-2
    • experimental reproduction
    • experimental inoculation
    • conventional pigs
    • parvovirus
    • disease
    • mutations
    • infection

    Cite this

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    abstract = "In this study, 60 pigs with clinical signs of post-weaning multisystemic wasting syndrome (PMWS) from 20 different pig herds and 180 control pigs (without clinical signs of PMWS) were examined to get more insights into the frequencies of porcine circovirus 2 infections and the presence of co-infections in pigs with and without clinical signs of PMWS in the Netherlands. Porcine circovirus type 2 was detected in 100{\%} of the pigs with clinical signs of PMWS by virus isolation and/or PCR and in 50{\%} of the pigs from PMWS-free herds. There was an association between the levels of infectious PCV2 and/or PCV2 DNA load and the severity of clinical signs as described for PMWS. A high variation in PCV2 antibody titres was found in the clinically affected pigs, and 27{\%} of these pigs did not mount PCV2 antibody titres higher than 1:200. A concurrent infection of PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) was found in at least 83{\%} of the pigs with clinical signs of PMWS and in 35{\%} of the pigs from PMWS-free herds. Co-infections of European- and American-type PRRSV were detected only in PMWS herds and in one control herd with a history of PMWS clinical signs",
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    The presence of co-infections in pigs with clinical signs of PMWS in the Nethrlands: a case-control study. / Wellenberg, G.J.; Stockhofe, N.; Boersma, W.J.A.; Jong, M.F.; Elbers, A.R.W.

    In: Research in Veterinary Science, Vol. 77, No. 2, 2004, p. 177-184.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Stockhofe, N.

    AU - Boersma, W.J.A.

    AU - Jong, M.F.

    AU - Elbers, A.R.W.

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    KW - mutations

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