The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy

M. Vujkovic, J.H.M. de Vries, J. Lindemans, N.S. Macklon, P.J. van der Spek, E.A.P. Steegers, R.P.M. Steegers-Theunissen

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Abstract

Objective: To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers of the homocysteine pathway. Design: Observational prospective study. Setting: A tertiary referral fertility clinic at the Erasmus University Medical Centre, Rotterdam, The Netherlands. Patient(s): One hundred sixty-one couples undergoing IVF/ICSI treatment. Intervention(s): No interventions other than the Dutch governmental recommendation of folic acid. Main Outcome Measure(s): Dietary patterns, blood and follicular fluid concentrations of folate, vitamin B12, vitamin B6, homocysteine, and fertilization rate, embryo quality, and pregnancy. Result(s): In women, two dietary patterns were identified. The "health conscious-low processed" dietary pattern (variation explained 12.1%) was characterized by high intakes of fruits, vegetables, fish, and whole grains and low intakes of snacks, meats, and mayonnaise, and positively correlated with red blood cell folate (beta=0.07). The "Mediterranean" dietary pattern (variation explained 9.1%), that is, high intakes of vegetable oils, vegetables, fish, and legumes and low intakes of snacks, was positively correlated with red blood cell folate (beta=0.13), and vitamin B6 in blood (beta=0.09) and follicular fluid (beta=0.18). High adherence by the couple to the "Mediterranean" diet increased the probability of pregnancy, odds ratio 1.4 (95% confidence interval 1.0-1.9). Conclusion(s): A preconception "Mediterranean" diet by couples undergoing IVF/ICSI treatment contributes to the success of achieving pregnancy. (Fertil Steril (R) 2010; 94: 2096-101. (C) 2010 by American Society for Reproductive Medicine.)
Original languageEnglish
Pages (from-to)2096-2101
JournalFertility and Sterility
Volume94
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • life-style factors
  • folic-acid
  • energy-intake
  • homocysteine
  • fertility
  • folate
  • implantation
  • performance
  • population
  • impact

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