The potential impact of membrane cascading on downstream processing of oligosaccharides

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To assess the potential use of ideal nanofiltration cascades for the industrial fractionation of oligosac- charides, simulations of single, three and five stage NF cascades were carried out.Three and five stage ideal cascades show significant improvement in separation with diafiltration compared to single stage systems.The calculations do imply different membrane areas in each stage of the cascade.The ratio of the sieving coefficients of abinary mixture over the membrane plays an important role in determining the relation between yield and purity in a cascade system.A thigh sieving coefficient ratios ,both yield and purity increase concurrently in a three stage system,whereas at a low ratio of the sieving coefficients, the yield and purity become inversely proportional on the retentate side. In a five stage systems,both yield and purity become inversely proportional at high and low sieving coefficient ratios. A five stage cascade system installation would be optima lfor most applications since at very low local separation factors sufficient separation and yield could be achieved.
Original languageEnglish
Pages (from-to)86-98
JournalChemical Engineering Science
Issue number2014
Publication statusPublished - 2014


  • nanofiltration
  • separation
  • ultrafiltration
  • chromatography
  • fractionation
  • purification
  • saccharides

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