The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots

Luca Santuari, Gabino F. Sanchez-Perez, Marijn Luijten, Bas Rutjens, Inez Terpstra, Lidija Berke, Maartje Gorte, Kalika Prasad, Dongping Bao, Johanna L.P.M. Timmermans-Hereijgers, Kenichiro Maeo, Kenzo Nakamura, Akie Shimotohno, Ales Pencik, Ondrej Novak, Karin Ljung, Sebastiaan Van Heesch, Ewart De Bruijn, Edwin Cuppen, Viola Willemsen & 6 others Ari Pekka Mähönen, Wolfgang Lukowitz, Berend Snel, Dick De Ridder, Ben Scheres, Renze Heidstra

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Abstract

Organ formation in animals and plants relies on precise control of cell state transitions to turn stem cell daughters into fully differentiated cells. In plants, cells cannot rearrange due to shared cell walls. Thus, differentiation progression and the accompanying cell expansion must be tightly coordinated across tissues. PLETHORA (PLT) transcription factor gradients are unique in their ability to guide the progression of cell differentiation at different positions in the growing Arabidopsis thaliana root, which contrasts with well-described transcription factor gradients in animals specifying distinct cell fates within an essentially static context. To understand the output of the PLT gradient, we studied the gene set transcriptionally controlled by PLTs. Our work reveals how the PLT gradient can regulate cell state by region-specific induction of cell proliferation genes and repression of differentiation. Moreover, PLT targets include major patterning genes and autoregulatory feedback components, enforcing their role as master regulators of organ development.
Original languageEnglish
Pages (from-to)2937-2951
JournalThe Plant Cell
Volume28
Issue number12
DOIs
Publication statusPublished - 2016

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Santuari, L., Sanchez-Perez, G. F., Luijten, M., Rutjens, B., Terpstra, I., Berke, L., ... Heidstra, R. (2016). The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots. The Plant Cell, 28(12), 2937-2951. https://doi.org/10.1105/tpc.16.00656