The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots

Ikram Billou, Jian Xu, Marjolein Wildwater, Viola Willemsen, Ivan Paponov, Jiří Frimi, Renze Heidstra, Mitsuhiro Aida, Klaus Palme, Ben Scheres*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1215 Citations (Scopus)

Abstract

Local accumulation of the plant growth regulator auxin mediates pattern formation in Arabidopsis roots and influences outgrowth and development of lateral root- and shoot-derived primordia. However, it has remained unclear how auxin can simultaneously regulate patterning and organ outgrowth and how its distribution is stabilized in a primordium-specif ic manner. Here we show that five PIN genes collectively control auxin distribution to regulate cell division and cell expansion in the primary root. Furthermore, the joint action of these genes has an important role in pattern formation by focusing the auxin maximum and restricting the expression domain of PLETHORA (PLT) genes, major determinants for root stem cell specification. In turn, PLT genes are required for PIN gene transcription to stabilize the auxin maximum at the distal root tip. Our data reveal an interaction network of auxin transport facilitators and root fate determinants that control patterning and growth of the root primordium.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalNature
Volume433
Issue number7021
DOIs
Publication statusPublished - 6 Jan 2005
Externally publishedYes

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