The physics of tissue formation with mesenchymal stem cells

G.A. Higuera, A.J.B. van Boxtel, C.A. van Blitterswijk, L. Moroni

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4 Citations (Scopus)

Abstract

Cells react to various forms of physical phenomena that promote and maintain the formation of tissues. The best example of this are cells of musculoskeletal origin, such as mesenchymal stem cells (MSCs), which consistently proliferate or differentiate under cues from hydrostatic pressure, diffusive mass transport, shear stress, surface chemistry, mechanotransduction, and molecular kinetics. To date, no other cell type shows greater receptiveness to macroscopic and microscopic cues, highlighting the acute sensitivity of MSCs and the importance of physical principles in tissue homeostasis. In this review, we describe the literature that has shown how physical phenomena govern MSCs biology and provide insight into the mechanisms and strategies that can spur new biotechnological applications with tissue biology.
Original languageEnglish
Pages (from-to)583-590
JournalTrends in Biotechnology
Volume30
Issue number11
DOIs
Publication statusPublished - 2012

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Keywords

  • bone-marrow
  • chondrogenic differentiation
  • mechanical-properties
  • bioreactor system
  • shear-stress
  • iron-oxide
  • in-vitro
  • expansion
  • proliferation
  • micro

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