The path from beta-Carotene to Carlactone, a Strigolactone-Like Plant Hormone

J. Alder, M. Jamil, M. Marzorati, F. Bruno, J. Bigler, H.J. Bouwmeester, P. Beyer, S. Al-Babili

Research output: Contribution to journalArticleAcademicpeer-review

434 Citations (Scopus)

Abstract

Strigolactones, phytohormones with diverse signaling activities, have a common structure consisting of two lactones connected by an enol-ether bridge. Strigolactones derive from carotenoids via a pathway involving the carotenoid cleavage dioxygenases 7 and 8 (CCD7 and CCD8) and the iron-binding protein D27. We show that D27 is a ß-carotene isomerase that converts all-trans-ß-carotene into 9-cis-ß-carotene, which is cleaved by CCD7 into a 9-cis–configured aldehyde. CCD8 incorporates three oxygens into 9-cis-ß-apo-10'-carotenal and performs molecular rearrangement, linking carotenoids with strigolactones and producing carlactone, a compound with strigolactone-like biological activities. Knowledge of the structure of carlactone will be crucial for understanding the biology of strigolactones and may have applications in combating parasitic weeds.
Original languageEnglish
Pages (from-to)1348-1351
Number of pages4
JournalScience
Volume335
Issue number6074
DOIs
Publication statusPublished - 2012

Keywords

  • cleavage oxygenases
  • biosynthesis
  • germination
  • striga
  • inhibition
  • metabolism
  • orobanche
  • catalyze
  • enzymes

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    Alder, J., Jamil, M., Marzorati, M., Bruno, F., Bigler, J., Bouwmeester, H. J., Beyer, P., & Al-Babili, S. (2012). The path from beta-Carotene to Carlactone, a Strigolactone-Like Plant Hormone. Science, 335(6074), 1348-1351. https://doi.org/10.1126/science.1218094