The P gene of Newcastle disease virus does not encode an accessory X protein

B.P.H. Peeters, P. Verbruggen, F. Nelissen, O.S. de Leeuw

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    14 Citations (Scopus)


    Many paramyxoviruses encode non-essential accessory proteins that are involved in the regulation of virus replication and inhibition of cellular antiviral responses. It has been suggested that the P gene mRNA of Newcastle disease virus (NDV) encodes an accessory protein ¿ the so-called X protein ¿ by translation initiation at a conserved in-frame AUG codon at position 120. Using a monoclonal antibody that specifically detected the P and X proteins, it was shown that an accessory X protein was not expressed in NDV-infected cells. Recombinant NDV strains in which the AUG was changed into a GCC (Ala) or GUC (Val) codon were viable but showed a reduction in virulence, probably because the amino acid change affected the function of the P and/or V protein.
    Original languageEnglish
    Pages (from-to)2375-2378
    JournalJournal of General Virology
    Issue number8
    Publication statusPublished - 2004


    • v-protein
    • interferon-antagonist
    • messenger-rna
    • c-protein
    • expression
    • cells
    • pathogenicity


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