The organoid era permits the development of new applications to study glioblastoma

Francesco Andreatta, Giulia Beccaceci, Nicolò Fortuna, Martina Celotti, Dario De Felice, Marco Lorenzoni, Veronica Foletto, Sacha Genovesi, Josep Rubert, Alessandro Alaimo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)


Glioblastoma (GB) is the most frequent and aggressive type of glioma. The lack of reliable GB models, together with its considerable clinical heterogeneity, has impaired a comprehensive investigation of the mechanisms that lead to tumorigenesis, cancer progression, and response to treatments. Recently, 3D cultures have opened the possibility to overcome these challenges and cerebral organoids are emerging as a leading-edge tool in GB research. The opportunity to easily engineer brain organoids via gene editing and to perform co-cultures with patient-derived tumor spheroids has enabled the analysis of cancer development in a context that better mimics brain tissue architecture. Moreover, the establishment of biobanks from GB patient-derived organoids represents a crucial starting point to improve precision medicine therapies. This review exemplifies relevant aspects of 3D models of glioblastoma, with a specific focus on organoids and their involvement in basic and translational research.

Original languageEnglish
Article number3303
Pages (from-to)1-16
Number of pages16
Issue number11
Publication statusPublished - Nov 2020
Externally publishedYes


  • Glioblastoma
  • Organoids
  • Precision medicine
  • Preclinical cancer models
  • Stem cells
  • Translational research
  • Tumoroids


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