The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda

Paul E. Verweij*, John A. Lucas, Maiken C. Arendrup, Paul Bowyer, Arjen J.F. Brinkmann, David W. Denning, Paul S. Dyer, Matthew C. Fisher, Petra L. Geenen, Ulrich Gisi, Dietrich Hermann, Andre Hoogendijk, Eric Kiers, Katrien Lagrou, Willem J.G. Melchers, Johanna Rhodes, Anton G. Rietveld, Sijmen E. Schoustra, Klaus Stenzel, Bas J. ZwaanBart A. Fraaije

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as a possible cause for development of resistance, which increases the complexity and number of stakeholders involved in this emerging problem. A workshop was held in Amsterdam early 2019 in which stakeholders, including medical and agricultural researchers, representatives from the government, public health, fungicide producers and end-users, reviewed the current evidence supporting environmental selection for resistance and to discuss which research and measures are needed to retain the effectiveness of the azole class for environmental and medical applications. This paper provides an overview of the latest insights and understanding of azole resistance development in the clinical setting and the wider environment. A One Health problem approach was undertaken to list and prioritize which research will be needed to provide missing evidence and to enable preventive interventions.

Original languageEnglish
Pages (from-to)202-214
JournalFungal Biology Reviews
Volume34
Issue number4
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Aspergillus fumigatus
  • Azole resistance
  • Demethylase inhibitor
  • Expert meeting
  • Fungicide

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