The journey of resveratrol from yeast to human

Silvie Timmers, Johan Auwerx, Patrick Schrauwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

132 Citations (Scopus)

Abstract

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
Original languageEnglish
Pages (from-to)146-158
Number of pages13
JournalAging
Volume4
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Keywords

  • Aging
  • Calorie restriction
  • Metabolic diseases
  • Resveratrol
  • SIRT1
  • Sirtuins

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