The journey of resveratrol from yeast to human

Silvie Timmers, Johan Auwerx, Patrick Schrauwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

140 Citations (Scopus)


The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
Original languageEnglish
Pages (from-to)146-158
Number of pages13
Issue number3
Publication statusPublished - Mar 2012
Externally publishedYes


  • Aging
  • Calorie restriction
  • Metabolic diseases
  • Resveratrol
  • SIRT1
  • Sirtuins


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