The intestinal microenvironment and functional gastrointestinal disorders

Giovanni Barbara*, Christine Feinle-Bisset, Uday C. Ghoshal, Javier Santos, Stepen J. Vanner, Nathalie Vergnolle, Erwin G. Zoetendal, Eamonn M. Quigley

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

113 Citations (Scopus)

Abstract

For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, although not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management. Not surprisingly, given its exploration in many disease states, the gut microbiota has also been studied in functional gastrointestinal disorders; data remain inconclusive. Likewise, there is also a considerable body of experimental and some clinical data to link the pathogenesis of functional gastrointestinal disorders to disturbances in epithelial barrier integrity, abnormal enteroendocrine signaling, and immune activation. These data provide growing evidence supporting the existence of micro-organic changes, particularly in subgroups of patients with functional dyspepsia and irritable bowel syndrome. However, their exact role in the complex pathophysiology and symptom generation of functional gastrointestinal disorders needs to be further studied and elucidated, particularly with longitudinal and interventional studies.

Original languageEnglish
Pages (from-to)1305-1318.e8
JournalGastroenterology
Volume150
Issue number6
DOIs
Publication statusPublished - 2016

Keywords

  • Bile Acids
  • Food
  • Functional Dyspepsia
  • Immune System
  • Irritable Bowel Syndrome
  • Microbiota
  • Serotonin

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    Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016). The intestinal microenvironment and functional gastrointestinal disorders. Gastroenterology, 150(6), 1305-1318.e8. https://doi.org/10.1053/j.gastro.2016.02.028