The Inflammasome Puts Obesity in the Danger Zone

R. Stienstra, C.J. Tack, T.D. Kanneganti, L.A.B. Joosten, M.G. Netea

Research output: Contribution to journalArticleAcademicpeer-review

175 Citations (Scopus)

Abstract

Obesity-induced inflammation is an important contributor to the induction of insulin resistance. Recently, the cytokine interleukin-1 beta (IL-1 beta) has emerged as a prominent instigator of the proinflammatory response in obesity. Several studies over the last year have subsequently deciphered the molecular mechanisms responsible for IL-1 beta activation in adipose tissue, liver, and macrophages and demonstrated a central role of the processing enzyme caspase-1 and of the protein complex leading to its activation called the inflammasome. These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes.
Original languageEnglish
Pages (from-to)10-18
JournalCell Metabolism
Volume15
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • thioredoxin-interacting protein
  • saturated fatty-acids
  • chronic granulomatous-disease
  • induced insulin-resistance
  • islet amyloid polypeptide
  • type-2 diabetes-mellitus
  • adipose-tissue
  • caspase-1 activation
  • nlrp3 inflammasome
  • metabolic syndrome

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