The Inflammasome Puts Obesity in the Danger Zone

R. Stienstra; C.J. Tack; T.D. Kanneganti; L.A.B. Joosten; M.G. Netea

doi:10.1016/j.cmet.2011.10.011

The Inflammasome Puts Obesity in the Danger Zone

R. Stienstra, C.J. Tack, T.D. Kanneganti, L.A.B. Joosten, M.G. Netea

Research output: Contribution to journal › Article › Academic › peer-review

228 Citations (Scopus)

Abstract

Obesity-induced inflammation is an important contributor to the induction of insulin resistance. Recently, the cytokine interleukin-1 beta (IL-1 beta) has emerged as a prominent instigator of the proinflammatory response in obesity. Several studies over the last year have subsequently deciphered the molecular mechanisms responsible for IL-1 beta activation in adipose tissue, liver, and macrophages and demonstrated a central role of the processing enzyme caspase-1 and of the protein complex leading to its activation called the inflammasome. These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes.

Original language	English
Pages (from-to)	10-18
Journal	Cell Metabolism
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2011.10.011
Publication status	Published - 2012

Keywords

thioredoxin-interacting protein
saturated fatty-acids
chronic granulomatous-disease
induced insulin-resistance
islet amyloid polypeptide
type-2 diabetes-mellitus
adipose-tissue
caspase-1 activation
nlrp3 inflammasome
metabolic syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cmet.2011.10.011Licence: Publisher

Cite this

@article{aceb8c6fa91f49c596ec014fdc882901,

title = "The Inflammasome Puts Obesity in the Danger Zone",

abstract = "Obesity-induced inflammation is an important contributor to the induction of insulin resistance. Recently, the cytokine interleukin-1 beta (IL-1 beta) has emerged as a prominent instigator of the proinflammatory response in obesity. Several studies over the last year have subsequently deciphered the molecular mechanisms responsible for IL-1 beta activation in adipose tissue, liver, and macrophages and demonstrated a central role of the processing enzyme caspase-1 and of the protein complex leading to its activation called the inflammasome. These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes.",

keywords = "thioredoxin-interacting protein, saturated fatty-acids, chronic granulomatous-disease, induced insulin-resistance, islet amyloid polypeptide, type-2 diabetes-mellitus, adipose-tissue, caspase-1 activation, nlrp3 inflammasome, metabolic syndrome",

author = "R. Stienstra and C.J. Tack and T.D. Kanneganti and L.A.B. Joosten and M.G. Netea",

note = "WOS:000299656700006",

year = "2012",

doi = "10.1016/j.cmet.2011.10.011",

language = "English",

volume = "15",

pages = "10--18",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - The Inflammasome Puts Obesity in the Danger Zone

AU - Stienstra, R.

AU - Tack, C.J.

AU - Kanneganti, T.D.

AU - Joosten, L.A.B.

AU - Netea, M.G.

N1 - WOS:000299656700006

PY - 2012

Y1 - 2012

N2 - Obesity-induced inflammation is an important contributor to the induction of insulin resistance. Recently, the cytokine interleukin-1 beta (IL-1 beta) has emerged as a prominent instigator of the proinflammatory response in obesity. Several studies over the last year have subsequently deciphered the molecular mechanisms responsible for IL-1 beta activation in adipose tissue, liver, and macrophages and demonstrated a central role of the processing enzyme caspase-1 and of the protein complex leading to its activation called the inflammasome. These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes.

AB - Obesity-induced inflammation is an important contributor to the induction of insulin resistance. Recently, the cytokine interleukin-1 beta (IL-1 beta) has emerged as a prominent instigator of the proinflammatory response in obesity. Several studies over the last year have subsequently deciphered the molecular mechanisms responsible for IL-1 beta activation in adipose tissue, liver, and macrophages and demonstrated a central role of the processing enzyme caspase-1 and of the protein complex leading to its activation called the inflammasome. These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes.

KW - thioredoxin-interacting protein

KW - saturated fatty-acids

KW - chronic granulomatous-disease

KW - induced insulin-resistance

KW - islet amyloid polypeptide

KW - type-2 diabetes-mellitus

KW - adipose-tissue

KW - caspase-1 activation

KW - nlrp3 inflammasome

KW - metabolic syndrome

U2 - 10.1016/j.cmet.2011.10.011

DO - 10.1016/j.cmet.2011.10.011

M3 - Article

SN - 1550-4131

VL - 15

SP - 10

EP - 18

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

The Inflammasome Puts Obesity in the Danger Zone

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this