The importance of endophenotypes to evaluate the relationship between genotype and external phenotype

Marinus F.W. te Pas*, Ole Madsen, Mario P.L. Calus, Mari A. Smits

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

With the exception of a few Mendelian traits, almost all phenotypes (traits) in livestock science are quantitative or complex traits regulated by the expression of many genes. For most of the complex traits, differential expression of genes, rather than genomic variation in the gene coding sequences, is associated with the genotype of a trait. The expression profiles of the animal’s transcriptome, proteome and metabolome represent endophenotypes that influence/regulate the externally-observed phenotype. These expression profiles are generated by interactions between the animal’s genome and its environment that range from the cellular, up to the husbandry environment. Thus, understanding complex traits requires knowledge about not only genomic variation, but also environmental effects that affect genome expression. Gene products act together in physiological pathways and interaction networks (of pathways). Due to the lack of annotation of the functional genome and ontologies of genes, our knowledge about the various biological systems that contribute to the development of external phenotypes is sparse. Furthermore, interaction with the animals’ microbiome, especially in the gut, greatly influences the external phenotype. We conclude that a detailed understanding of complex traits requires not only understanding of variation in the genome, but also its expression at all functional levels.

Original languageEnglish
Article number472
JournalInternational Journal of Molecular Sciences
Volume18
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Bioinformatics
  • Genomic variation and environment
  • Integration
  • Livestock science
  • Metabolome
  • Methylome
  • Phenome
  • Proteome
  • Systems biology
  • Transcriptome

Fingerprint Dive into the research topics of 'The importance of endophenotypes to evaluate the relationship between genotype and external phenotype'. Together they form a unique fingerprint.

  • Cite this