TY - JOUR
T1 - The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond
T2 - Implications for Allergy and Asthma
AU - van Esch, Betty C.A.M.
AU - Porbahaie, Mojtaba
AU - Abbring, Suzanne
AU - Garssen, Johan
AU - Potaczek, Daniel P.
AU - Savelkoul, Huub F.J.
AU - van Neerven, R.J.J.
PY - 2020/10/21
Y1 - 2020/10/21
N2 - Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is important at all stages of life, it is especially important in prenatal and the first few years of life. During the last decade, there has been a growing interest in the potential role of epigenetic mechanisms in the increasing health problems associated with allergic disease. Epigenetics involves several mechanisms including DNA methylation, histone modifications, and microRNAs which can modify the expression of genes. In this study, we focus on the effects of maternal nutrition during pregnancy, the effects of the bioactive components in human and bovine milk, and the environmental factors that can affect early life (i.e., farming, milk processing, and bacterial exposure), and which contribute to the epigenetic mechanisms underlying the persistent programming of immune functions and allergic diseases. This knowledge will help to improve approaches to nutrition in early life and help prevent allergies in the future.
AB - Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is important at all stages of life, it is especially important in prenatal and the first few years of life. During the last decade, there has been a growing interest in the potential role of epigenetic mechanisms in the increasing health problems associated with allergic disease. Epigenetics involves several mechanisms including DNA methylation, histone modifications, and microRNAs which can modify the expression of genes. In this study, we focus on the effects of maternal nutrition during pregnancy, the effects of the bioactive components in human and bovine milk, and the environmental factors that can affect early life (i.e., farming, milk processing, and bacterial exposure), and which contribute to the epigenetic mechanisms underlying the persistent programming of immune functions and allergic diseases. This knowledge will help to improve approaches to nutrition in early life and help prevent allergies in the future.
KW - allergy
KW - bioactive milk components
KW - breastfeeding
KW - environmental factors
KW - epigenetic imprinting
KW - epigenetics
KW - nutritional programming
KW - unprocessed (raw) milk
U2 - 10.3389/fimmu.2020.02141
DO - 10.3389/fimmu.2020.02141
M3 - Article
AN - SCOPUS:85095712625
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 2141
ER -