The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)

P. Cahn; K. Ruxrungtham; B. Gazzard; K. van Norren; R.S. Diaz; A. Gori; D.P. Kotler; A. Vriesema; N.A. Georgiou; J. Garssen; M. Clerici; J.M.A. Lange

doi:10.1093/cid/cit171

The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)

P. Cahn
, K. Ruxrungtham
, B. Gazzard
, K. van Norren
, R.S. Diaz
, A. Gori
, D.P. Kotler
, A. Vriesema
, N.A. Georgiou
, J. Garssen
, M. Clerici
, J.M.A. Lange

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

Abstract

Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts

Original language	English
Pages (from-to)	139-146
Journal	Clinical infectious diseases
Volume	57
Issue number	1
DOIs	https://doi.org/10.1093/cid/cit171
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

virus type-1 infection
viral load
bovine colostrum
pathogenesis
restoration
enteropathy
prebiotics
depletion
survival
mucosa

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Cahn, P., Ruxrungtham, K., Gazzard, B., van Norren, K., Diaz, R. S., Gori, A., Kotler, D. P., Vriesema, A., Georgiou, N. A., Garssen, J., Clerici, M., & Lange, J. M. A. (2013). The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). Clinical infectious diseases, 57(1), 139-146. https://doi.org/10.1093/cid/cit171

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abstract = "Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts",

keywords = "virus type-1 infection, viral load, bovine colostrum, pathogenesis, restoration, enteropathy, prebiotics, depletion, survival, mucosa",

author = "P. Cahn and K. Ruxrungtham and B. Gazzard and \{van Norren\}, K. and R.S. Diaz and A. Gori and D.P. Kotler and A. Vriesema and N.A. Georgiou and J. Garssen and M. Clerici and J.M.A. Lange",

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publisher = "Oxford University Press",

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Cahn, P, Ruxrungtham, K, Gazzard, B, van Norren, K, Diaz, RS, Gori, A, Kotler, DP, Vriesema, A, Georgiou, NA, Garssen, J, Clerici, M & Lange, JMA 2013, 'The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)', Clinical infectious diseases, vol. 57, no. 1, pp. 139-146. https://doi.org/10.1093/cid/cit171

The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). / Cahn, P.; Ruxrungtham, K.; Gazzard, B. et al.
In: Clinical infectious diseases, Vol. 57, No. 1, 2013, p. 139-146.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)

AU - Cahn, P.

AU - Ruxrungtham, K.

AU - Gazzard, B.

AU - van Norren, K.

AU - Diaz, R.S.

AU - Gori, A.

AU - Kotler, D.P.

AU - Vriesema, A.

AU - Georgiou, N.A.

AU - Garssen, J.

AU - Clerici, M.

AU - Lange, J.M.A.

PY - 2013

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N2 - Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts

AB - Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts

KW - virus type-1 infection

KW - viral load

KW - bovine colostrum

KW - pathogenesis

KW - restoration

KW - enteropathy

KW - prebiotics

KW - depletion

KW - survival

KW - mucosa

U2 - 10.1093/cid/cit171

DO - 10.1093/cid/cit171

M3 - Article

SN - 1058-4838

VL - 57

SP - 139

EP - 146

JO - Clinical infectious diseases

JF - Clinical infectious diseases

IS - 1

ER -

Cahn P, Ruxrungtham K, Gazzard B, van Norren K, Diaz RS, Gori A et al. The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). Clinical infectious diseases. 2013;57(1):139-146. doi: 10.1093/cid/cit171