The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)

P. Cahn; K. Ruxrungtham; B. Gazzard; K. van Norren; R.S. Diaz; A. Gori; D.P. Kotler; A. Vriesema; N.A. Georgiou; J. Garssen; M. Clerici; J.M.A. Lange

doi:10.1093/cid/cit171

The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)

P. Cahn, K. Ruxrungtham, B. Gazzard, K. van Norren, R.S. Diaz, A. Gori, D.P. Kotler, A. Vriesema, N.A. Georgiou, J. Garssen, M. Clerici, J.M.A. Lange

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts

Original language	English
Pages (from-to)	139-146
Journal	Clinical infectious diseases
Volume	57
Issue number	1
DOIs	https://doi.org/10.1093/cid/cit171
Publication status	Published - 2013

Keywords

virus type-1 infection
viral load
bovine colostrum
pathogenesis
restoration
enteropathy
prebiotics
depletion
survival
mucosa

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cahn, P., Ruxrungtham, K., Gazzard, B., van Norren, K., Diaz, R. S., Gori, A., Kotler, D. P., Vriesema, A., Georgiou, N. A., Garssen, J., Clerici, M., & Lange, J. M. A. (2013). The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). Clinical infectious diseases, 57(1), 139-146. https://doi.org/10.1093/cid/cit171

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abstract = "Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts",

keywords = "virus type-1 infection, viral load, bovine colostrum, pathogenesis, restoration, enteropathy, prebiotics, depletion, survival, mucosa",

author = "P. Cahn and K. Ruxrungtham and B. Gazzard and {van Norren}, K. and R.S. Diaz and A. Gori and D.P. Kotler and A. Vriesema and N.A. Georgiou and J. Garssen and M. Clerici and J.M.A. Lange",

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Cahn, P, Ruxrungtham, K, Gazzard, B, van Norren, K, Diaz, RS, Gori, A, Kotler, DP, Vriesema, A, Georgiou, NA, Garssen, J, Clerici, M & Lange, JMA 2013, 'The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)', Clinical infectious diseases, vol. 57, no. 1, pp. 139-146. https://doi.org/10.1093/cid/cit171

The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). / Cahn, P.; Ruxrungtham, K.; Gazzard, B. et al.
In: Clinical infectious diseases, Vol. 57, No. 1, 2013, p. 139-146.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Cahn, P.

AU - Ruxrungtham, K.

AU - Gazzard, B.

AU - van Norren, K.

AU - Diaz, R.S.

AU - Gori, A.

AU - Kotler, D.P.

AU - Vriesema, A.

AU - Georgiou, N.A.

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AB - Background The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)–infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. Methods In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1–positive adults not on antiretroviral therapy, with CD4+ T-cell counts

KW - virus type-1 infection

KW - viral load

KW - bovine colostrum

KW - pathogenesis

KW - restoration

KW - enteropathy

KW - prebiotics

KW - depletion

KW - survival

KW - mucosa

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JO - Clinical infectious diseases

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Cahn P, Ruxrungtham K, Gazzard B, van Norren K, Diaz RS, Gori A et al. The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-Cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). Clinical infectious diseases. 2013;57(1):139-146. doi: 10.1093/cid/cit171