The genome editing revolution

John van der Oost*, Constantinos Patinios*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)

Abstract

A series of spectacular scientific discoveries and technological advances in the second half of the 20th century have provided the basis for the ongoing genome editing revolution. The elucidation of structural and functional features of DNA and RNA was followed by pioneering studies on genome editing: Molecular biotechnology was born. Since then, four decades followed during which progress of scientific insights and technological methods continued at an overwhelming pace. Fundamental insights into microbial host-virus interactions led to the development of tools for genome editing using restriction enzymes or the revolutionary CRISPR-Cas technology. In this review, we provide a historical overview of milestones that led to the genome editing revolution and speculate about future trends in biotechnology.

Original languageEnglish
Pages (from-to)396-409
Number of pages14
JournalTrends in Biotechnology
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 2023

Keywords

  • biotechnology
  • CRISPR-Cas
  • genome editing
  • recombineering

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