The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

Claudia E. Coipan; Gilian L.A. van Duijvendijk; Tim R. Hofmeester; Katsuhisa Takumi; Hein Sprong

doi:10.1186/s13071-018-3006-2

The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

Claudia E. Coipan^*, Gilian L.A. van Duijvendijk, Tim R. Hofmeester, Katsuhisa Takumi, Hein Sprong

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.

Original language	English
Article number	454
Journal	Parasites and Vectors
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13071-018-3006-2
Publication status	Published - 6 Aug 2018

Keywords

Borrelia burgdorferi (s.l.)
dbpA
IGS
Ixodes ricinus larvae
ospC
Rodents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13071-018-3006-2Licence: CC BY

The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts
Coipan, C. E. (Creator), van Duijvendijk, L. A. G. (Creator), Hofmeester, T. R. (Creator), Takumi, K. (Creator) & Sprong, H. (Creator), Wageningen University, 6 Aug 2018
DOI: 10.6084/m9.figshare.c.4190291
Dataset

Cite this

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title = "The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts",

abstract = "Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.",

keywords = "Borrelia burgdorferi (s.l.), dbpA, IGS, Ixodes ricinus larvae, ospC, Rodents",

author = "Coipan, {Claudia E.} and {van Duijvendijk}, {Gilian L.A.} and Hofmeester, {Tim R.} and Katsuhisa Takumi and Hein Sprong",

year = "2018",

month = aug,

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doi = "10.1186/s13071-018-3006-2",

language = "English",

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journal = "Parasites and Vectors",

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T1 - The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

AU - Coipan, Claudia E.

AU - van Duijvendijk, Gilian L.A.

AU - Hofmeester, Tim R.

AU - Takumi, Katsuhisa

AU - Sprong, Hein

PY - 2018/8/6

Y1 - 2018/8/6

N2 - Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.

AB - Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.

KW - Borrelia burgdorferi (s.l.)

KW - dbpA

KW - IGS

KW - Ixodes ricinus larvae

KW - ospC

KW - Rodents

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DO - 10.1186/s13071-018-3006-2

M3 - Article

AN - SCOPUS:85051172806

SN - 1756-3305

VL - 11

JO - Parasites and Vectors

JF - Parasites and Vectors

IS - 1

M1 - 454

ER -

The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

Abstract

Keywords

UN SDGs

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The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

Cite this