The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

Claudia E. Coipan, Gilian L.A. van Duijvendijk, Tim R. Hofmeester, Katsuhisa Takumi, Hein Sprong

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.

Original languageEnglish
Article number454
JournalParasites and Vectors
Volume11
Issue number1
DOIs
Publication statusPublished - 6 Aug 2018

Fingerprint

Borrelia burgdorferi Group
Rodentia
Arvicolinae
Ticks
Shrews
Murinae
Ixodes
Genetic Loci
Haplotypes
Larva
Mammals
Plasmids
Infection

Keywords

  • Borrelia burgdorferi (s.l.)
  • dbpA
  • IGS
  • Ixodes ricinus larvae
  • ospC
  • Rodents

Cite this

Coipan, C. E., van Duijvendijk, G. L. A., Hofmeester, T. R., Takumi, K., & Sprong, H. (2018). The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts. Parasites and Vectors, 11(1), [454]. https://doi.org/10.1186/s13071-018-3006-2
Coipan, Claudia E. ; van Duijvendijk, Gilian L.A. ; Hofmeester, Tim R. ; Takumi, Katsuhisa ; Sprong, Hein. / The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts. In: Parasites and Vectors. 2018 ; Vol. 11, No. 1.
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abstract = "Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.",
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The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts. / Coipan, Claudia E.; van Duijvendijk, Gilian L.A.; Hofmeester, Tim R.; Takumi, Katsuhisa; Sprong, Hein.

In: Parasites and Vectors, Vol. 11, No. 1, 454, 06.08.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts

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AU - van Duijvendijk, Gilian L.A.

AU - Hofmeester, Tim R.

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AU - Sprong, Hein

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N2 - Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.

AB - Background: Small mammals are essential in the enzootic cycle of many tick-borne pathogens (TBP). To understand their contribution to the genetic diversity of Borrelia afzelii, the most prevalent TBP in questing Ixodes ricinus, we compared the genetic variants of B. afzelii at three distinct genetic loci. We chose two plasmid loci, dbpA and ospC, and a chromosomal one, IGS. Results: While the larvae that fed on shrews (Sorex sp.) tested negative for B. afzelii, those fed on bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) showed high infection prevalences of 0.13 and 0.27, respectively. Despite the high genetic diversity within B. afzelii, there was no difference between wood mice and bank voles in the number and types of B. afzelii haplotypes they transmit. Conclusions: The genetic diversity in B. afzelii cannot be explained by separate enzootic cycles in wood mice and bank voles.

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