The fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization

C.A. Cuomo, U. Güldener, J.R. Xu, F. Trail, B.G. Turgeon, C. Waalwijk

    Research output: Contribution to journalArticleAcademicpeer-review

    563 Citations (Scopus)

    Abstract

    We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts
    Original languageEnglish
    Pages (from-to)1400-1402
    JournalScience
    Volume317
    Issue number5843
    DOIs
    Publication statusPublished - 2007

    Keywords

    • neurospora
    • dna

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