Biological control agents (BCAs) are potential alternatives for the chemical fungicides presently used in agriculture to fight plant diseases. Coniothyrium minitans is an example of a promising fungal BCA. It is a naturally occurring parasite of the fungus Sclerotinia sclerotiorum, a wide-spread pathogen which substantially reduces the yield of many crops. This review describes, exemplified by C. minitans, the studies that need to be carried out before a fungal BCA is successfully introduced into the market. The main aspects considered are the biology of C. minitans, the development of a product by mass production of spores using solid-state fermentation technology, its biocontrol activity and marketing of the final product.
de Vrije, T., Antoine, N., Buitelaar, R. M., Oostra, J., Rinzema, A., & Weber, F. J. (2001). The fungal biocontrol agent Coniothyrium minitans: production by solid-state fermentation, application and marketing. Applied Microbiology and Biotechnology, 56, 58-68. https://doi.org/10.1007/s002530100678