The first 1000 cultured species of the human gastrointestinal microbiota

M. Rajilic-Stojanovic, W.M. de Vos

Research output: Contribution to journalArticleAcademicpeer-review

420 Citations (Scopus)

Abstract

The microorganisms that inhabit the human gastrointestinal tract comprise a complex ecosystem with functions that significantly contribute to our systemic metabolism and have an impact on health and disease. In line with its importance, the human gastrointestinal microbiota has been extensively studied. Despite the fact that a significant part of the intestinal microorganisms has not yet been cultured, presently over 1000 different microbial species that can reside in the human gastrointestinal tract have been identified. This review provides a systematic overview and detailed references of the total of 1057 intestinal species of Eukarya (92), Archaea (8) and Bacteria (957), based on the phylogenetic framework of their small subunit ribosomal RNA gene sequences. Moreover, it unifies knowledge about the prevalence, abundance, stability, physiology, genetics and the association with human health of these gastrointestinal microorganisms, which is currently scattered over a vast amount of literature published in the last 150 years. This detailed physiological and genetic information is expected to be instrumental in advancing our knowledge of the gastrointestinal microbiota. Moreover, it opens avenues for future comparative and functional metagenomic and other high-throughput approaches that need a systematic and physiological basis to have an impact.
Original languageEnglish
Pages (from-to)996-1047
JournalFEMS Microbiology Reviews
Volume38
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • irritable-bowel-syndrome
  • 16s ribosomal-rna
  • human gut microbiota
  • gradient gel-electrophoresis
  • human intestinal microbiota
  • human fecal samples
  • mucin-degrading bacterium
  • equol-producing bacterium
  • diet-induced obesity
  • bottle-fed infants

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