The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana

Wen Biao Jiao, Vipul Patel*, Jonas Klasen, Fang Liu, Petra Pecinkova, Marina Ferrand, Isabelle Gy, Christine Camilleri, Sigi Effgen, Maarten Koornneef, Ales Pecinka, Olivier Loudet, Korbinian Schneeberger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


Although gene duplications provide genetic backup and allow genomic changes under relaxed selection, they may potentially limit gene flow. When different copies of a duplicated gene are pseudofunctionalized in different genotypes, genetic incompatibilities can arise in their hybrid offspring. Although such cases have been reported after manual crosses, it remains unclear whether they occur in nature and how they affect natural populations. Here, we identified four duplicated-gene based incompatibilities including one previously not reported within an artificial Arabidopsis intercross population. Unexpectedly, however, for each of the genetic incompatibilities we also identified the incompatible alleles in natural populations based on the genomes of 1,135 Arabidopsis accessions published by the 1001 Genomes Project. Using the presence of incompatible allele combinations as phenotypes for GWAS, we mapped genomic regions that included additional gene copies which likely rescue the genetic incompatibility. Reconstructing the geographic origins and evolutionary trajectories of the individual alleles suggested that incompatible alleles frequently coexist, even in geographically closed regions, and that their effects can be overcome by additional gene copies collectively shaping the evolutionary dynamics of duplicated genes during population history.

Original languageEnglish
Pages (from-to)1225-1240
Number of pages16
JournalMolecular Biology and Evolution
Issue number4
Early online date28 Nov 2020
Publication statusPublished - Apr 2021


  • duplicated gene
  • genetic incompatibility
  • genome-wide association study
  • HPA
  • loss of function
  • TIM22


Dive into the research topics of 'The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana'. Together they form a unique fingerprint.

Cite this