The effects of fat loss after bariatric surgery on inflammation, serum hepcidin, and iron absorption: A prospective 6-mo iron stable isotope study

Ana C. Cepeda-Lopez*, Javier Allende-Labastida, Alida Melse-Boonstra, Saskia J.M. Osendarp, Isabelle Herter-Aeberli, Diego Moretti, Ramiro Rodriguez-Lastra, Francisco Gonzalez-Salazar, Salvador Villalpando, Michael B. Zimmermann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Background: Iron deficiency is common in obese subjects. This may be due to an increase in serum hepcidin and a decrease in iron absorption from adiposity-related inflammation. Objective: We evaluated whether weight and fat loss in obese subjects would decrease inflammation and serum hepcidin and thereby improve iron absorption. Design: We performed a 6-mo prospective study in obese [body mass index (in kg/m2) ≥ 35 and <45] adults who had recently undergone laparoscopic sleeve gastrectomy. At 2 and 8 mo postsurgery, subjects consumed a test drink with 6 mg 57Fe as ferrous sulfate and were intravenously infused with 100 μg 58Fe as iron citrate. We then compared erythrocyte incorporation of iron isotopic labels, changes in body composition, iron status, hepcidin, and inflammation at each time point. Results: Forty-three subjects were studied at baseline, and 38 completed the protocol (32 women and 6 men). After 6 mo, total body fat, interleukin IL-6, and hepcidin were significantly lower (all P <0.005). In iron-deficient subjects (n = 17), geometric mean (95% CI) iron absorption increased by 28% [from 9.7% (6.5%, 14.6%) to 12.4% (7.7%, 20.1%); P = 0.03], whereas in iron-sufficient subjects (n = 21), absorption did not change [5.9% (4.0%, 8.6%) and 5.6% (3.9%, 8.2%); P = 0.81]. Conclusion: Adiposity-related inflammation is associated with a reduction in the normal upregulation of iron absorption in iron-deficient obese subjects, and this adverse effect may be ameliorated by fat loss. This protocol was approved by the ethics committees of Wageningen University, ETH Zurich, the University of Monterrey, and the Federal Commission for the Protection against Sanitary Risks, and registered at clinicaltrials.gov as NCT01347905.

Original languageEnglish
Pages (from-to)1030-1038
JournalAmerican Journal of Clinical Nutrition
Volume104
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Hepcidin
  • Inflammation
  • Iron absorption
  • Iron deficiency
  • Obesity
  • Stable isotopes

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    Cepeda-Lopez, A. C., Allende-Labastida, J., Melse-Boonstra, A., Osendarp, S. J. M., Herter-Aeberli, I., Moretti, D., Rodriguez-Lastra, R., Gonzalez-Salazar, F., Villalpando, S., & Zimmermann, M. B. (2016). The effects of fat loss after bariatric surgery on inflammation, serum hepcidin, and iron absorption: A prospective 6-mo iron stable isotope study. American Journal of Clinical Nutrition, 104(4), 1030-1038. https://doi.org/10.3945/ajcn.115.115592