The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial

Mark R. van Loenen; Lianne B. Remie; Mara P.H. van Trijp; Michelle G. Jansen; José P. Marques; Jurgen A.H.R. Claassen; Ondine van de Rest; Yannick Vermeiren; Nynke Smidt; Sietske A.M. Sikkes; Kay Deckers; Marissa D. Zwan; Wiesje M. van der Flier; Sebastian Köhler; Wilma T. Steegenga; Joukje M. Oosterman; Esther Aarts

doi:10.2196/preprints.69814

The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial

Mark R. van Loenen
, Lianne B. Remie
, Mara P.H. van Trijp
, Michelle G. Jansen
, José P. Marques
, Jurgen A.H.R. Claassen
, Ondine van de Rest
, Yannick Vermeiren
, Nynke Smidt
, Sietske A.M. Sikkes
, Kay Deckers
, Marissa D. Zwan
, Wiesje M. van der Flier
, Sebastian Köhler
, Wilma T. Steegenga
, Joukje M. Oosterman
, Esther Aarts

Research output: Working paper › Preprint

Abstract

Studies of multidomain lifestyle interventions show mixed results on preventing or delaying cognitive decline in ageing. A better understanding of the mechanisms underlying these interventions could help explain these mixed findings.

Original language	English
Publisher	JMIR Publications
Number of pages	64
DOIs	https://doi.org/10.2196/preprints.69814
Publication status	Published - 11 Dec 2024

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The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial
van Loenen, M. R., Remie, L. B., van Trijp, M. P. H., Jansen, M. G., Marques, J. P., Claassen, J., van de Rest, O., Vermeiren, Y., Smidt, N., Sikkes, S. A. M., Deckers, K., Zwan, M. D., van der Flier, W. M., Köhler, S., Steegenga, W. T., Oosterman, J. M. & Aarts, E., 15 Oct 2025, In: JMIR Research Protocols. 14, p. e69814-e69814
Research output: Contribution to journal › Article › Academic › peer-review

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van Loenen, M. R., Remie, L. B., van Trijp, M. P. H., Jansen, M. G., Marques, J. P., Claassen, J. A. H. R., van de Rest, O., Vermeiren, Y., Smidt, N., Sikkes, S. A. M., Deckers, K., Zwan, M. D., van der Flier, W. M., Köhler, S., Steegenga, W. T., Oosterman, J. M., & Aarts, E. (2024). The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial. JMIR Publications. https://doi.org/10.2196/preprints.69814

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title = "The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial",

abstract = "Studies of multidomain lifestyle interventions show mixed results on preventing or delaying cognitive decline in ageing. A better understanding of the mechanisms underlying these interventions could help explain these mixed findings.",

author = "\{van Loenen\}, \{Mark R.\} and Remie, \{Lianne B.\} and \{van Trijp\}, \{Mara P.H.\} and Jansen, \{Michelle G.\} and Marques, \{Jos{\'e} P.\} and Claassen, \{Jurgen A.H.R.\} and \{van de Rest\}, Ondine and Yannick Vermeiren and Nynke Smidt and Sikkes, \{Sietske A.M.\} and Kay Deckers and Zwan, \{Marissa D.\} and \{van der Flier\}, \{Wiesje M.\} and Sebastian K{\"o}hler and Steegenga, \{Wilma T.\} and Oosterman, \{Joukje M.\} and Esther Aarts",

year = "2024",

month = dec,

day = "11",

doi = "10.2196/preprints.69814",

language = "English",

publisher = "JMIR Publications",

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van Loenen, MR, Remie, LB, van Trijp, MPH, Jansen, MG, Marques, JP, Claassen, JAHR, van de Rest, O, Vermeiren, Y, Smidt, N, Sikkes, SAM, Deckers, K, Zwan, MD, van der Flier, WM, Köhler, S, Steegenga, WT, Oosterman, JM & Aarts, E 2024 'The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial' JMIR Publications. https://doi.org/10.2196/preprints.69814

The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial. / van Loenen, Mark R.; Remie, Lianne B.; van Trijp, Mara P.H. et al.
JMIR Publications, 2024.

Research output: Working paper › Preprint

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AU - van Trijp, Mara P.H.

AU - Jansen, Michelle G.

AU - Marques, José P.

AU - Claassen, Jurgen A.H.R.

AU - van de Rest, Ondine

AU - Vermeiren, Yannick

AU - Smidt, Nynke

AU - Sikkes, Sietske A.M.

AU - Deckers, Kay

AU - Zwan, Marissa D.

AU - van der Flier, Wiesje M.

AU - Köhler, Sebastian

AU - Steegenga, Wilma T.

AU - Oosterman, Joukje M.

AU - Aarts, Esther

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BT - The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial

PB - JMIR Publications

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van Loenen MR, Remie LB, van Trijp MPH, Jansen MG, Marques JP, Claassen JAHR et al. The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial. JMIR Publications. 2024 Dec 11. doi: 10.2196/preprints.69814

The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers and intestinal health in older adults at-risk of cognitive ageing: study design and baseline characteristics of the HELI randomized controlled trial

Abstract

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Research output

The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial

Cite this