The effector GpRBP-1, a cornerstone in understanding potato cyst nematode-host compatibility

Vera Putker

doi:10.18174/681303

The effector GpRBP-1, a cornerstone in understanding potato cyst nematode-host compatibility

Vera Putker

Research output: Thesis › internal PhD, WU

Abstract

Potato cyst nematodes form a significant threat to the potato production worldwide. These nematodes secrete effector proteins in the host to manipulate the host cells, evade plant immunity and promote disease. In my thesis, I aim to gain a deeper understanding in the compatible interaction between the plant parasitic nematode Globodera pallida and its host, potato plants, by leveraging the model effector GpRBP-1. By using molecular and cellular approaches, we found that GpRBP-1 has several molecular targets in the host, making GpRBP-1 a multifunctional effector protein contributing to compatibility with the host. Despite the role of GpRBP-1 in host-compatibility, we leveraged the leveraged the G. pallida genome and we found that GpRBP-1 does not contribute to breaking the matching resistance gene Gpa2.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Wageningen University
Supervisors/Advisors	Goverse, Aska, Promotor Sterken, Mark, Co-promotor
Award date	15 May 2025
Place of Publication	Wageningen
Publisher	Wageningen University
DOIs	https://doi.org/10.18174/681303
Publication status	Published - 15 May 2025

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Molecular mechanisms translated to the acre: Using the tripartite interaction model between the Solanum tuberosum immune receptor Gpa2, its co-factor RanGAP2 and the matching Globodera pallida effector RBP1 as a fundament for understanding nematode resistance and virulence in the field.
Putker, V. (PhD candidate), Goverse, A. (Promotor) & Sterken, M. (Co-promotor)
1/08/20 → 15/05/25
Project: PhD

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title = "The effector GpRBP-1, a cornerstone in understanding potato cyst nematode-host compatibility",

abstract = "Potato cyst nematodes form a significant threat to the potato production worldwide. These nematodes secrete effector proteins in the host to manipulate the host cells, evade plant immunity and promote disease. In my thesis, I aim to gain a deeper understanding in the compatible interaction between the plant parasitic nematode Globodera pallida and its host, potato plants, by leveraging the model effector GpRBP-1. By using molecular and cellular approaches, we found that GpRBP-1 has several molecular targets in the host, making GpRBP-1 a multifunctional effector protein contributing to compatibility with the host. Despite the role of GpRBP-1 in host-compatibility, we leveraged the leveraged the G. pallida genome and we found that GpRBP-1 does not contribute to breaking the matching resistance gene Gpa2.",

author = "Vera Putker",

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N2 - Potato cyst nematodes form a significant threat to the potato production worldwide. These nematodes secrete effector proteins in the host to manipulate the host cells, evade plant immunity and promote disease. In my thesis, I aim to gain a deeper understanding in the compatible interaction between the plant parasitic nematode Globodera pallida and its host, potato plants, by leveraging the model effector GpRBP-1. By using molecular and cellular approaches, we found that GpRBP-1 has several molecular targets in the host, making GpRBP-1 a multifunctional effector protein contributing to compatibility with the host. Despite the role of GpRBP-1 in host-compatibility, we leveraged the leveraged the G. pallida genome and we found that GpRBP-1 does not contribute to breaking the matching resistance gene Gpa2.

AB - Potato cyst nematodes form a significant threat to the potato production worldwide. These nematodes secrete effector proteins in the host to manipulate the host cells, evade plant immunity and promote disease. In my thesis, I aim to gain a deeper understanding in the compatible interaction between the plant parasitic nematode Globodera pallida and its host, potato plants, by leveraging the model effector GpRBP-1. By using molecular and cellular approaches, we found that GpRBP-1 has several molecular targets in the host, making GpRBP-1 a multifunctional effector protein contributing to compatibility with the host. Despite the role of GpRBP-1 in host-compatibility, we leveraged the leveraged the G. pallida genome and we found that GpRBP-1 does not contribute to breaking the matching resistance gene Gpa2.

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U2 - 10.18174/681303

DO - 10.18174/681303

M3 - internal PhD, WU

PB - Wageningen University

CY - Wageningen

ER -

The effector GpRBP-1, a cornerstone in understanding potato cyst nematode-host compatibility

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Molecular mechanisms translated to the acre: Using the tripartite interaction model between the Solanum tuberosum immune receptor Gpa2, its co-factor RanGAP2 and the matching Globodera pallida effector RBP1 as a fundament for understanding nematode resistance and virulence in the field.

Cite this