The effect of vitamin E supplementation on serum DHEA and neopterin levels in elderly subjects

J. van Amsterdam, J. van der Horst-Graat, E. Bischoff, P. Steerenberg, A. Opperhuizen, E.G. Schouten

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Abstract

Contradictory results have been published on the immune-stimulating effects of vitamin E. Using a randomized placebo-controlled design, the effect of 15 month¿s daily supplementation with 200 mg vitamin E on two biomarkers of immunocompetence, i.e. serum DHEA sulfate ester (DHEA-S) and neopterin, was studied. Of the 100 relatively healthy Dutch elderly subjects included in the study, 50 were supplemented with vitamin E and 50 received placebo. As compared to placebo, vitamin E supplementation affected neither serum DHEA-S nor serum neopterin level. This corroborates with the finding that vitamin E supplementation did not affect infection-related severity measures, i.e. total number of days with respiratory infection, and total duration of the infections. It is concluded that vitamin E supplementation does not substantially alter the immunocompetence markers DHEA and neopterin in elderly subjects, and may explain our recently reported failure of vitamin E supplementation to afford protection against acute respiratory infections.
Original languageEnglish
Pages (from-to)327-331
JournalInternational Journal for Vitamin and Nutrition Research
Volume75
Issue number5
DOIs
Publication statusPublished - 2005

Keywords

  • randomized controlled-trial
  • nutritional-status
  • alpha-tocopherol
  • immune-response
  • age
  • dehydroepiandrosterone
  • men
  • infections
  • women
  • association

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    van Amsterdam, J., van der Horst-Graat, J., Bischoff, E., Steerenberg, P., Opperhuizen, A., & Schouten, E. G. (2005). The effect of vitamin E supplementation on serum DHEA and neopterin levels in elderly subjects. International Journal for Vitamin and Nutrition Research, 75(5), 327-331. https://doi.org/10.1024/0300-9831.75.5.327