Contradictory results have been published on the immune-stimulating effects of vitamin E. Using a randomized placebo-controlled design, the effect of 15 month¿s daily supplementation with 200 mg vitamin E on two biomarkers of immunocompetence, i.e. serum DHEA sulfate ester (DHEA-S) and neopterin, was studied. Of the 100 relatively healthy Dutch elderly subjects included in the study, 50 were supplemented with vitamin E and 50 received placebo. As compared to placebo, vitamin E supplementation affected neither serum DHEA-S nor serum neopterin level. This corroborates with the finding that vitamin E supplementation did not affect infection-related severity measures, i.e. total number of days with respiratory infection, and total duration of the infections. It is concluded that vitamin E supplementation does not substantially alter the immunocompetence markers DHEA and neopterin in elderly subjects, and may explain our recently reported failure of vitamin E supplementation to afford protection against acute respiratory infections.
|Journal||International Journal for Vitamin and Nutrition Research|
|Publication status||Published - 2005|
- randomized controlled-trial
van Amsterdam, J., van der Horst-Graat, J., Bischoff, E., Steerenberg, P., Opperhuizen, A., & Schouten, E. G. (2005). The effect of vitamin E supplementation on serum DHEA and neopterin levels in elderly subjects. International Journal for Vitamin and Nutrition Research, 75(5), 327-331. https://doi.org/10.1024/0300-98184.108.40.2067